自拟射干麻黄汤治疗急性发作期慢性支气管炎的临床效果

Clinical effect of self-made Shegan Mahuang Decoction on acute exacerbation of chronic bronchitis

目的探讨自拟射干麻黄汤治疗急性发作期慢性支气管炎的临床效果。方法选取2016年1月～2017年12月宜兴市人民医院收治的93例急性发作期慢性支气管炎患者为研究对象,按随机数字表法分为对照组和治疗组,其中对照组46例、治疗组47例。对照组予常规治疗,治疗组在对照组治疗基础上联合自拟射干麻黄汤治疗,两组均治疗10 d。比较两组的住院时间及喘息、咳嗽、咳痰缓解时间。比较两组临床疗效、血氧饱和度(SpO_2)、动脉血氧分压(PaO_2)、动脉血二氧化碳分压(PaCO_2)及血清白细胞介素-8(IL-8)、超敏C反应蛋白(hs-CRP)、肿瘤坏死因子α(TNF-α)、γ干扰素(IFN-γ)水平。记录并比较两组治疗过程中不良反应发生情况。结果治疗组总有效率高于对照组,差异有统计学意义(P <0.05)。治疗组的住院时间及喘息、咳嗽、咳痰缓解时间均明显短于对照组,差异有高度统计学意义(P <0.01)。两组治疗后SpO_2、PaO_2水平均明显高于治疗前(P <0.05),且治疗组高于对照组(P <0.01);两组治疗后PaCO_2及血清IL-8、hs-CRP、TNF-α、IFN-γ水平均明显低于治疗前(P <0.05),且治疗组低于对照组(P <0.01)。治疗组的不良反应发生率低于对照组(P <0.05)。结论自拟射干麻黄汤治疗急性发作期慢性支气管炎的临床效果显著,能够明显缩短治疗时间,减轻炎性反应,改善呼吸道通气功能,且安全性较好。

Objective To study the clinical efficacy of self-made Shegan Mahuang Decoction in treatment of acute exacerbation of chronic bronchitis.Methods A total of 93 patients with acute exacerbation of chronic bronchitis admitted in Yixing People′s Hospital from January 2016 to December 2017 were selected as subjects,and they were divided into control group and treatment group by random number table method,with 46 cases in the control group and 47 cases in the treatment group.The control group was treated with conventional treatment,the treatment group was treated with self-made Shegan Mahuang Decoction on basis of the treatment in the control group.The two groups were treated for 10 days.Hospitalization time,wheezing,cough and expectoration relieving time were compared between the two groups.Clinical efficacy,levels of blood oxygen saturation(SpO2),arterial oxygen partial pressure(PaO2),arterial carbondioxide partial pressure(PaCO2),serum interleukin-8(IL-8),high-sensitivity c-reactive protein(hs-CRP),tumor necrosis factor alpha(TNF-α),interferon-gamma(IFN-γ)were compared between the two groups.Adverse reactions were recorded and compared between the two groups.Results The total effective rate of the treatment group was significantly higher than that of the control group and the difference was statistically significant(P<0.05).The hospitalization time,wheezing,cough and expectoration relieving time in the treatment group were significantly shorter than those in the control group,the difference was highly statistically significant(P<0.01).After treatment,the levels of SpO2 and PaO2 in the two groups were significantly higher than those before treatment(P<0.05),and the indices in the treatment group were higher than those in the control group(P<0.01).Levels of PaCO2,serum IL-8,hs-CRP,TNF-α,IFN-γwere lower than those before treatment significantly(P<0.05),and those in the treatment group were lower than the control group(P<0.01).The adverse reaction rate of the treatment group was significantly lower than that of the control group(P<0.05).Conclusion Self-made Shegan Mahuang Decoction in treatment of acute exacerbation of chronic bronchitis has good efficacy,which can shorten the treatment time obviously,reduce inflammation and improve respiratory tract ventilation function,and it has good safety.