加味胃苓汤对肝硬化腹水患者肠道菌群的影响

Effect of Jiawei Weiling Decoction on the Intestinal Microflora in Patients with Cirrhosis Ascites

目的:观察加味胃苓汤对肝硬化腹水患者肠道菌群的影响。方法:70例肝硬化腹水患者随机分为治疗组与对照组,每组35例,另取35例健康医护人员作为健康组。对照组患者给予常规西药综合治疗,治疗组患者在常规西药综合治疗基础上,加服中药加味胃苓汤,疗程均为4周。观察两组患者治疗前后粪便细菌培养中常见细菌(肠杆菌、肠球菌、葡萄球菌、酵母菌、拟杆菌、双歧杆菌、梭菌、乳酸杆菌)的变化。结果:(1)与健康人比,肝硬化腹水患者肠道菌群肠杆菌、肠球菌、葡萄球菌、酵母菌数量显著增加(P <0. 01),拟杆菌、双歧杆菌、梭菌、乳酸杆菌数量显著下降(P <0.05)。(2)治疗组患者经加味胃苓汤治疗后肠道菌群肠杆菌、肠球菌、葡萄球菌数量显著下降(P <0. 05),拟杆菌、乳酸杆菌数量显著增加(P <0.05);4周治疗后,两组患者比较,治疗组肠道肠杆菌、肠球菌、葡萄球菌数量较对照组低,拟杆菌、乳酸杆菌数量较对照组高(P <0.05)。结论:肝硬化腹水患者存在肠道菌群失衡,表现为肠道肠杆菌、肠球菌、葡萄球菌、酵母菌数量增加,拟杆菌、双歧杆菌、梭菌、乳酸杆菌数量下降。加味胃苓汤可有效改善肝硬化腹水患者的肠道菌群失调情况。

Objective:To observe the effect of Jiawei Wuling Decoction on intestinal microflora in patients with cirrhosis ascites.Methods:70 cases patients with Liver cirrhosis ascites were divided randomly into the control group and the therapeutic group.Each group had 35 cases.Another 35 health people were taken as the normal control group.All patients were treated with routine western medicine.on the base of these,the therapeutic group was treated with Jiawei Weiling Decoction,every day a decoction,for 4 weeks.Before treatment,the feces of each group for common bacterial culture in the intestinal tract were taken.After 4 weeks treatment,comparison of the results of bacteria culture in each group were taken to evaluate the effect of Jiawei Weiling Decoction.Results:Compared with health people,The number of Enterobacteriaceae,Enterococcus,Staphylococcus and Yeast increased significantly in the patients with cirrhotic ascites(P<0.01),and the number of Bacteroides,Bifidobacteria,Clostridium and Lactobacillus decreased significantly(P<0.05).After treatment,the number of Enterobacteriaceae,Enterococcus and Staphylococcus in the treatment group decreased significantly(P<0.05)and the number of Bacteroides and Lactobacillus increased significantly(P<0.05).Conclusion:The imbalance of intestinal flora exists in patients with ascites due to cirrhosis.The number of Enterobacteriaceae,Enterococcus,Staphylococcus and Yeast increased.The number of Bacteroides,Bifidobacteria,Clostridium and Lactobacillus decreased.Jiawei Weiling Decoction can effectively improve intestinal flora imbalance in patients with cirrhosis ascites.