肝硬化合并门脉血栓形成的危险因素分析

Analysis of risk factors on cirrhosis with portal vein thrombosis

目的:探讨肝硬化合并门脉血栓形成(PVT)的危险因素。方法:选取88例肝硬化合并PVT患者(简称为PVT组)和肝硬化未合并PVT的患者88例为对照组,统计分析两组患者的一般资料、实验室相关检查指标,采用多因素分析法探讨肝硬化并发PVT的危险因素。结果:两组患者的年龄、性别、基础病因、合并高血压、合并糖尿病、WBC、PLT、TBil、INR、APTT、FIB、PT、MELD评分差异无统计学意义(P> 0. 05); PVT组患者的Hb、Alb、D-D、门静脉主干内径宽度、脾静脉内径宽度与对照组比较差异具有统计学意义(P <0. 05);采用非条件Logistic回归分析结果显示:Hb和Alb降低、D-D升高、门静脉主干内径宽度、脾静脉内径宽度增加是肝硬化患者并发PVT的独立危险因素(P <0. 05)。结论:Hb和Alb降低、D-D升高、脾静脉内径宽度增加是肝硬化患者并发PVT的独立危险因素。

Objective:To explore the risk factors of cirrhosis with portal vein thrombosis(PVT).Methods:88 cases of cirrhosis with PVT(PVT group)were selected.From January 2014 to September 2016,88 patients with co-cirrhosis without PVT were selected.The general data of the two groups were analyzed statistically.The risk factors of cirrhosis complicated with PVT were investigated by multivariate analysis.Results:PVT group and control group in age,gender,underlying disease,hypertension,diabetes,WBC,PLT,TBil,INR,APTT,FIB,PT,MELD score difference were statistically significant(P>0.05);the difference were statistically significant in PVT group were Hb,Alb,D-D,portal vein diameter,width the width of splenic vein and the control group(P<0.05);using non conditional Logistic regression analysis showed that Hb decreased,ALB decreased,D-D increased,the diameter of splenic vein width were independent risk factors in patients with liver cirrhosis complicated with PVT(P<0.05).Conclusion:The decrease of Hb,the decrease of Alb,the elevation of D-D and the increase of the width of splenic vein were the independent risk factors of PVT in patients with cirrhosis.