血清甲胎蛋白水平与儿童肝母细胞瘤临床特征之间的相关性

Correlation between serum alpha fetoprotein level and clinical characteristics in children with hepatblastoma

目的:观察儿童肝母细胞瘤的临床特征与血清甲胎蛋白水平之间的相关性研究。方法:临床选择2016年5月～2017年3月儿童肝母细胞瘤患者100例,予以免疫荧光法检测全部研究对象的血清甲胎蛋白水平,评估全部研究对象手术前后、化疗前后、是否出现复发、预后生存期等临床指标与血清甲胎蛋白水平的相关性。结果:儿童肝母细胞瘤Ⅰ～Ⅱ期者46例,血清甲胎蛋白水平为(3654. 7±134. 5) ng/ml,Ⅲ～Ⅳ期者54例,血清甲胎蛋白水平为(7982. 4±257. 6) ng/ml,差异有统计学意义(t=102. 60,P <0. 01)。儿童肝母细胞瘤手术前血清甲胎蛋白水平为(6854. 6±145. 7) ng/ml,手术后血清甲胎蛋白水平为(3256. 8±35. 9) ng/ml,差异有统计学意义(t=239. 76,P <0. 01)。100例儿童肝母细胞瘤,复发20例,血清甲胎蛋白水平正常者2例,未复发者80例,血清甲胎蛋白水平正常者45例,差异有统计学意义(χ2=11. 95,P <0. 01)。预后生存期1～3年者60例,血清甲胎蛋白水平正常者34例,预后生存期<1年者40例,血清甲胎蛋白水平正常者13例,差异有统计学意义(χ2=4. 70,P <0. 05)。儿童肝母细胞瘤的临床分期、手术情况、化疗情况、复发、预后生存期与血清甲胎蛋白水平密切相关,差异有统计学意义(P <0. 05)。结论:肝母细胞瘤病人的临床病情与血清甲胎蛋白水平密切相关,病人在治疗后1个月内血清甲胎蛋白水平下降至正常者说明病人预后较佳。

Objective:To observe the correlation between hepatoblastoma and serum alpha fetoprotein(AFP).Methods:100 hepatoblastoma children underoging the immunofluorescence method from May 2016 to March 2017 were selected.The recurrence rate,survival time and AFP were evaluated.Results:The AFP contents in stage I-II(n=46)and stage III-IV of children(n=54)were(3654.7±134.5)ng/ml and(7982.4±257.6)ng/ml(t=102.60,P<0.01);before and after surgery,the AFP contents were(6854.6±145.7)ng/ml and(3256.8±35.9)ng/ml(t=239.76,P<0.01);2 cases had the normal AFP in 20 recurrent children;45 cases had the normal AFP in 80 non-recurrent children(χ^2=11.95,P<0.01);34 cases had the normal AFP in 60 children with 1-3 survival time;13 cases had the normal AFP in 40 children with<1 survival time(χ^2=4.70,P<0.05);the clinical staging,operation conditions,chemotherapy,recurrence rate and survival time were closely correlated with AFP contents(P<0.05).Conclusion:The clinical features are closely correlated with AFP contents;within 1month of surgery,the AFP contents return to normal,indicating the children have the favorable prognosis.