摘要
非酒精性脂肪性肝病是全球性的公共卫生问题。调整生活方式及保持健康心理状态是治疗非酒精性脂肪性肝病的基础。本文通过对其发病机理研究的梳理,重点介绍了近年来国内外关于非酒精性脂肪性肝病药物治疗的进展,包括氧化应激、炎症反应、脂质代谢、纤维形成和细胞凋亡等不同阶段靶向治疗药物应用的安全性和有效性。
Non-alcoholic fatty liver disease (NAFLD) is a global public health problem. Adjusting lifestyle and maintaining a healthy mental state are the cornerstones in dealing with patients with NAFLD. This article focuses on the recent progress at home and abroad in medical treatment of NAFLD and reviews the safety and efficacy of targeted therapies in different stages of oxidative stress,inflammatory response,lipid metabolism,fibrogenesis,and apoptosis.
作者
钟燕
苏淑婷
宓余强
Zhong Yan;Su Shuting;Mi Yuqiang(Graduate School,Tianjin Medical University,Tianjin,300070,China)
出处
《实用肝脏病杂志》
CAS
2019年第1期145-148,共4页
Journal of Practical Hepatology
关键词
非酒精性脂肪性肝病
氧化应激
治疗
Nonalcoholic fatty liver diseases
Oxidative stress
Treatment