非酒精性脂肪性肝病治疗研究进展

Treatment of patients with nonalcoholic fatty liver disease

非酒精性脂肪性肝病是全球性的公共卫生问题。调整生活方式及保持健康心理状态是治疗非酒精性脂肪性肝病的基础。本文通过对其发病机理研究的梳理,重点介绍了近年来国内外关于非酒精性脂肪性肝病药物治疗的进展,包括氧化应激、炎症反应、脂质代谢、纤维形成和细胞凋亡等不同阶段靶向治疗药物应用的安全性和有效性。

Non-alcoholic fatty liver disease (NAFLD) is a global public health problem. Adjusting lifestyle and maintaining a healthy mental state are the cornerstones in dealing with patients with NAFLD. This article focuses on the recent progress at home and abroad in medical treatment of NAFLD and reviews the safety and efficacy of targeted therapies in different stages of oxidative stress,inflammatory response,lipid metabolism,fibrogenesis,and apoptosis.