基于心肺同治法应用参蛤散治疗慢性心力衰竭

Treatment of chronic heart failure with Shenge Powder based on cardiopulmonary syndrome

[目的]观察参蛤散对慢性心力衰竭患者的中医证候积分、心功能分级、6分钟步行距离的影响,论证心肺同治法在慢性心力衰竭治疗中的作用。[方法]招募2015年4月—2018年1月期间在上海中医药大学附属龙华医院就诊的慢性心力衰竭患者,随机分为对照组和治疗组,对照组采用西医基础治疗,治疗组采用西医基础治疗联合使用参蛤散,疗程均为8周,研究者分别在治疗前后对所有受试者进行进行6分钟步行距离、中医证候积分及心功能分级的评估,并进行安全性指标诸如血尿粪常规、肝肾功能、电解质等相关检查。[结果]心功能分级的评价,对照组显效率为5.9%,有效率为55.9%,总有效率为61.8%;治疗组显效率为14.7%,有效率为67.6%,总有效率为82.3%。中医证候积分的评价,对照组显效率2.9%,有效率58.8%,总有效率为61.7%;治疗组显效率11.8%,有效率76.5%,总有效率为88.3%。6分钟步行距离疗效评价,对照组显效率为5.9%,有效率为52.9%,总有效率为58.8%;治疗组显效率为11.8%,有效率为70.6%,总有效率为82.4%。[结论]与对照组比较,治疗组更有助于改善慢性心力衰竭患者的心功能分级、中医证候积分和6分钟步行距离。

[Objective] To observe the effects of Shenge Powder on traditional Chinese medicine symptom scores,cardiac function grading,6-minute walking distance in patients with chronic heart failure,and to demonstrate the role of cardiopulmonary therapy in the treatment of chronic heart failure.[Methods] Patients with chronic heart failure who were admitted to Longhua Hospital affiliated to Shanghai University of Traditional Chinese Medicine from April 2015 to January 2018 were randomly divided into control group and treatment group according to the order of admission.The control group was treated with Western medicine.The treatment group The combination of Western medicine and Shenge Powder was used.The course of treatment was 8 weeks.All the subjects were treated from D0 to D56±1,safety indicators such as hematuria,liver and kidney function,electrolytes and other related tests were performed,and 6-minute walking distance,traditional Chinese medicine symptom scores and cardiac function grading were evaluated.[Results] At 8 weeks of treatment,the cardiac function of the two groups was graded.The most effective rate of the control group was 5.9%,the effective rate was 55.9%,and the total effective rate was 61.8%.The most effective rate of the treatment group was 14.7%,and the effective rate was 67.6%.The total effective rate was 82.3%;The traditional Chinese medicine syndrome score was evaluated.The control group showed an most effective rate of 2.9%,the effective rate was 58.8%,the total effective rate was 61.7%,the treatment group's most effective rate was 11.8%,the effective rate was 76.5%,and the total effective rate was 88.3%.The most efficacy of the six-minute walking distance was 5.9%,the effective rate was 52.9%,the total effective rate was 58.8%,the treatment group was 11.8%,the effective rate was 70.6%,and the total effective rate was 82.4%.[Conclusion] Compared with the control group,the treatment group is more helpful in improving cardiac function grading,traditional Chinese medicine symptom scores in patients with chronic heart failure.