丁苯酞注射液在基于TOAST分型的急性脑梗死中的疗效

Effect of butylphthalide injection on acute cerebral infarction patients with defferent TOAST types

目的探讨丁苯酞注射液对急性脑梗死TOAST不同亚型患者的疗效。方法急性脑梗死患者299例,随机分为两组。对照组按急性缺血性脑卒中诊治指南治疗,观察组在此基础上加用丁苯酞注射液。所有患者入院时均进行TOAST分型。并记录两组治疗前和治疗后2周、4周的美国国立卫生研究院卒中量表(NIHSS)评分和Barthel指数评定量表(BI)评分。比较两组及各亚型患者的疗效。结果与对照组比较,观察组治疗后2周、4周的NIHSS评分降低,BI评分升高(P <0.05),观察组治疗后疗效较对照组好(P <0.05)。3亚型治疗后NIHSS评分均有降低,BI评分均有增高。但是,LAA亚型变化得更明显,3亚型组间、不同时点及组间和不同时点的交互作用差异均有统计学意义(P <0.05)。结论丁苯酞注射液对急性脑梗死患者有较好的疗效。丁苯酞注射液在LAA亚型中的疗效好于CE和SAO亚型。

Objective To explore the efficacy of butylphthalide injection in the treatment of different subtypes of acute cerebral infarction(ACI),based on TOAST classification.MethodsA total of 299 patients with ACI were randomly divided into two groups.The control group was treated according to the guidelines for the diagnosis and treatment of acute ischemic stroke,while the observation group was treated with butylphthalide injection on the basis of the guidelines.All patients were carried out by TOAST typing on admission procedures.NIHSS score and BI score were recorded in two groups of patients on admission and after two weeks and four weeks of treatment.Comparison was performed in the curative effect of two groups and different subtypes of patients.Results Compared with the control group,the NIHSS score of observation group decreased while BI score increased after two weeks and four weeks of treatment(P<0.05).The curative effect of observation group was better than that of control group(P<0.05).After the treatment,the NIHSS of the three subtypes all saw decrease,while BI scores increased.However,LAA subtype changed more obviously.Significant statistical differences existed among the three subgroups,and among the interactions between the groups,at different time(P<0.05).Conclusion Butylphalide injection has a good effect on ACI.The effect of butylphthalide injection on LAA subtype are better than that of CE subtype and SAO subtype.