连续性血液净化联合乌司他丁对重症脓毒血症患者D-二聚体和降钙素原的影响

Effect of continuous blood purification combined with ulinastatin on D-dimer and procalcitonin in patients with severe sepsis

目的:探究应用连续性血液净化联合乌司他丁对重症脓毒血症患者D-二聚体和降钙素原的影响。方法:选取我院收治的68例重症浓毒血症患者(均为2017年4月～2018年4月)作为研究对象,根据随机数表法平均分成两组(对照组与观察组)。给予对照组连续血液透析治疗,观察组在对照组基础上联合乌司他丁进行治疗,对两组治疗前后D-二聚体与降钙素原水平进行记录。结果:两组治疗后,D-二聚体与降钙素原水平可见降低趋势,但观察组两个指标水平降低趋势较对照组显著,两组数据经统计,差异检验值为P<0.05。结论:应用连续性血液净化联合乌司他丁治疗重症脓毒血症,在改善微循环、抑制炎症因子方面具有显著优势,具有优良应用效果。

Objective:To explore the effect of continuous blood purification combined with ulinastatin on D-dimer and procalcitonin in patients with severe sepsis.Methods:A total of 68 patients with severe congestive diseases(all from April 2017 to April 2018)were selected as subjects.The patients were divided into two groups according to the random number method(control group and observation group).The control group was given continuous hemodialysis treatment,and the observation group was treated with ulinastatin on the basis of the control group.Results:After treatment,the levels of D-dimer and procalcitonin were decreased in the two groups.The decreasing trend of the two indicators in the observation group was significantly greater than that in the control group.The statistics of the two groups were statistically significant,P<0.05.Conclusion:The use of continuous blood purification combined with ulinastatin in patients with severe sepsis has significant advantages in improving microcirculation and inhibiting inflammatory factors,and has excellent application effects.