脊髓小胶质细胞调控神经病理性疼痛的分子机制及中医药干预的研究进展

Molecular mechanism of spinal microglia-induced neuropathic pain and research progress of intervention with traditional Chinese medicine

神经病理性疼痛(NP)临床干预棘手,目前仍无理想的治疗方法。既往研究多从神经元角度阐述NP发病机制,近年发现,在中枢神经系统,特别是脊髓水平的胶质细胞介导的神经炎症在NP病理演化过程中亦发挥重要作用。本文归纳了近年来脊髓水平小胶质细胞调节NP的分子机制及中医药干预的研究进展,期望为NP的临床有效干预及新药研发提供参考。

Neuropathic Pain(NP)has a difficult clinical intervention and there is still no ideal treatment.Previous studies have mostly explained the pathogenesis of NP from the perspective of neurons.In recent years,it has been found that glial cell-mediated neuroinflammation in the central nervous system,especially at the spinal level,also plays an important role in the pathological evolution of NP.In this paper,the molecular mechanism of glial cell regulation of NP in spinal cord and the progress of traditional Chinese medicine intervention in recent years are summarized.It is expected to provide reference for clinical effective intervention and new drug development of NP.