富马酸喹硫平片联合无抽搐电休克治疗老年双相情感障碍的效果观察

Effects of Quetiapine fumarate tablets combined with modified electric convulsive therapy on elderly patients with bipolar disorders

目的:观察富马酸喹硫平片联合无抽搐电休克治疗老年双相情感障碍的临床效果。方法:回顾性分析2015年6月至2017年6月的67例双相情感障碍老年患者的临床资料,按照治疗方案不同将其分为观察组33例与对照组34例。对照组给予富马酸喹硫平片治疗,观察组在对照组基础上给予无抽搐电休克治疗。比较治疗前后两组抑郁程度、躁狂症状变化情况及不良反应发生情况。结果:治疗后观察组汉密尔顿抑郁量表(HAMD)评分、躁狂量表(BRMS)评分明显低于对照组,差异均有统计学意义(P<0.05);两组副反应量表(TESS)评分比较,差异无统计学意义(P>0.05)。结论:富马酸喹硫平片联合无抽搐电休克治疗老年双相情感障碍的疗效确切,可明显改善患者的躁狂及抑郁状况,且安全性好。

Objective: To observe clinical effects of Quetiapine fumarate tablets combined with modified electric convulsive therapy(MECT) on elderly patients with bipolar disorders. Methods: The clinical data of 67 elderly patients with bipolar disorders were retrospectively analyzed. According to different treatment options, they were divided into observation group(33 cases) and control group(34 cases). The control group was treated with Quetiapine fumarate tablets, while the observation group was given MECT on the basis of that of the control group. The degree of depression, manic symptom changes and side effects were compared between the two groups before and after the treatment. Results: After the treatment, the scores of Hamilton depression scale(HAMD) and Bech-Rafaelsdn mania rating scale(BRMS) in the observation group were signifi cantly lower than those in the control group, and the differences were statistically signifi cant(P<0.05). However, there was no statistical difference in the treatment emergent symptom scale(TESS) score(P>0.05). Conclusions: Quetiapine fumarate tablets combined with MECT in the treatment of the elderly patients with bipolar disorders is effective defi nitely. Moreover, it can improve the manic and depression conditions with good safety.