摘要
目的观察CO_2气腹对妊娠中晚期大鼠血浆前列腺素E2(PGE2)水平的影响。方法 48只妊娠SD大鼠随机分为孕中期对照组、1 h气腹组、2 h气腹组及孕晚期对照组、1 h气腹组和2 h气腹组,用酶联免疫吸附法检测血浆PGE2水平。结果孕中期、晚期1 h气腹组血浆PGE2水平与同期对照组差异无统计学意义(P>0.05),而孕中期、晚期2 h气腹组血浆PGE2水平均显著高于同期对照组(P<0.05)。结论 CO_2气腹2 h可提高孕中、晚期大鼠血浆PGE2水平。
Objective To study the effect of carbon dioxide(CO2)pneumoperitoneum on plasma prostaglandin E2(PGE2)content in rats with medium and late pregnancy.Methods Forty-eight SD pregnant rats were randomized to medium and late pregnancy groups,and then subdivided into control and 1-h,2-h pneumoperitoneum subgroups.Plasma PGE2 level was measured by enzyme-linked immunosorbent assay.Results Compared with control group,plasma PGE2 content was increased in 2-h but not in 1-h pneumoperitoneum subgroups(P<0.05)despite of medium and late pregnancy.Conclusion The 2-h CO2 pneumoperitoneum can elevate plasma PGE2 level in rats with medium and late pregnancy.
作者
孙冰纯
洪龙年
黄海香
黄金智
张颖
SUN Bing-chun;HONG Long-nian;HUANG Hai-xiang;HUANG Jin-zhi;ZHANG Ying(Department of Obstetrics and Gynecology,Affiliated Hospital of Guangdong Medical University,Zhanjiang 524001,China)
出处
《广东医科大学学报》
2018年第6期636-637,共2页
Journal of Guangdong Medical University
基金
广东省科技计划资助项目(No.2008B030301019)
湛江市科技攻关计划项目(No.2015B01045)
广东医科大学科研基金项目(No.2XK14053)
关键词
CO2气腹
妊娠
大鼠
前列腺素E2
carbon dioxide pneumoperitoneum
pregnancy
rat
prostaglandin E2