阿托伐他汀钙辅助治疗脑梗死后认知功能障碍的效果观察

Curative effect of atorvastatin calcium on cognitive dysfunction caused by cerebral infarction

目的观察阿托伐他汀钙辅助治疗脑梗死后认知功能障碍的效果。方法 60例脑梗死后认知功能障碍患者随机分为对照组和治疗组,两组采用常规治疗3个月,治疗组增加口服阿托伐他汀钙片治疗。比较两组治疗前后血浆脂蛋白磷脂酶A2(Lp-PLA2)水平、认知功能障碍(MMSE)评分、Blessed行为量表(BBS)评分、事件相关电位P300情况。结果治疗后,治疗组MMSE评分高于对照组,BBS评分及Lp-PLA2水平低于对照组,P300潜伏期较对照组短、波幅较对照组大(P<0.05)。结论阿托伐他汀钙辅助治疗可明显改善脑梗死后认知功能障碍。

Objective To observe the clinical efficacy of atorvastatin calcium in patients with cognitive dysfunction following cerebral infarction.Methods Sixty patients cognitive dysfunction following cerebral infarction were randomly divided into control and treatment groups and treated with routine therapy for 3 months,while oral atorvastatin calcium tablets were complemental in treatment group.Plasma lipoprotein phospholipase A2(Lp-PLA2)level,mini-mental state examination(MMSE),blessed behavior scale(BBS),event-related potentials P300 were compared between two groups.Results There were incremental MMSE,reduced BBS and Lp-PLA2 level,and shorter latency and higher amplitude of P300 in treatment group compared with control group(P<0.05).Conclusion Adjuvant therapy of atorvastatin calcium can significantly improve the cognitive dysfunction after cerebral infarction.