半夏白术天麻汤联合安宫牛黄丸治疗早期高血压脑出血的临床研究

Clinical Research on Banxia Baizhu Tianma Decoction and Angong Niuhuang Pill in the Treatment of Early Hypertensive Intracerebral Hemorrhage

目的探讨半夏白术天麻汤联合安宫牛黄丸对早期高血压脑出血病人神经功能及血清S100B、胱抑素C(CysC)水平的影响。方法选取2013年8月—2017年1月于我院就诊的78例早期高血压脑出血病人,随机分为对照组(n=39)和观察组(n=39)。两组均采用常规西医治疗,对照组在常规西医治疗基础上采用安宫牛黄丸治疗,研究组在常规西医治疗基础上采用半夏白术天麻汤联合安宫牛黄丸治疗,两组均持续治疗14d。疗程结束后比较两组临床疗效、不良反应发生率、入院时及疗程结束后美国国立卫生研究院卒中量表评分(NIHSS)、日常生活能力量表评分(ADL)、格拉斯哥昏迷量表评分(GCS)、血清S100B及CysC水平、颅内压及血肿体积变化情况。结果治疗后,两组NIHSS评分较治疗前降低,ADL评分和GCS评分较治疗前升高,且研究组NIHSS评分低于对照组,ADL评分及GCS评分高于对照组(P <0.05)。研究组临床总有效率92.31%显著高于对照组69.23%(P <0.05)。治疗后,两组血清S100B、CysC水平较治疗前降低,且研究组低于对照组(P <0.05)。治疗后,两组颅内压及血肿体积均较治疗前减小,且研究组小于对照组(P <0.05)。研究组不良反应发生率与对照组比较,差异无统计学意义(P>0.05)。结论半夏白术天麻汤联合安宫牛黄丸治疗早期高血压脑出血可提高病人生活能力,改善神经功能。

Objective To investigate the effects of Banxia Baizhu Tianma decoction(BBTD)and Angong Niuhuang pill(ANP)on neuro-logical function and serum S100 B and Cystatin C(CysC)levels in patients with early hypertensive intracerebral hemorrhage.MethodsSeventy-eight patients with early hypertensive intracerebral hemorrhage from August 2013 to January 2017 were randomly divided intotwo groups:control group(n =39)treated with routine treatment,and study group(n =39)treated with BBTD and ANP in the basis ofroutine treatment for 14 days.The clinical efficacy,incidence of adverse events,National Institutes of Health Stroke Scale(NIHSS),ActivityDaily Rating Scale(ADL),Glasgow Coma Scale(GCS),serum S100 B,CysC levels,intracranial pressure,and hematoma volume changeswere observed.Results After treatment,the rate of effectivity in the study group was higher than that in the control group(92.31% vs69.23%,P <0.05).The levels of serum S100 B and CysC in the two groups after treatment were lower than those before treatment,and thestudy group was lower than that in the control group,the difference was statistically significant(P <0.05).After treatment,the intracra-nial pressure and hematoma volume in the two groups were lower than those before treatment,which the study group were lower than thosein the control group(P <0.05).There was no significant difference in the adverse reaction rate between the study group and the controlgroup(10.26%vs 7.69%,P >0.05).Conclusion BBTD and ANP can effectively improve the neurological function and daily living abil-ity in patients with early hypertensive intracerebral hemorrhage.