ATM缺失阻碍骨骼肌蛋白质合成的研究进展

Research Program of ATM Stunting Skeletal Muscle Protein Synthesis

恶性体质对国家财政和医疗资源造成极大浪费,而且直接影响个人健康状况和生活质量。毛细血管扩张共济失调(AT)疾病患者普遍身材矮小、肌力和运动能力下降,认为ATM与骨骼肌蛋白质合成有强关联性。文章梳理AT病人与骨骼肌、运动能力的相关实例,简述骨骼肌蛋白质合成机制和ATM与相关分子的调控关系,提出ATM阻碍骨骼肌蛋白质合成的路径假设。

Cachexia is caused great waste of national finance and medical resources,and directly affect the personal health and quality of life.Ataxia telangiectasia patients generally short stature,decreased muscle strength and exercise capacity,there are strong association of ATM and skeletal muscle protein synthesis.In this paper,present the AT patients with skeletal muscle,athletic related instances,description mechanism of skeletal muscle protein synthesis and ATM with related molecular regulation relationship,suggestion ATM stunting the path of the skeletal muscle protein synthesis hypothesis.