六味补气颗粒剂联合舒利迭治疗COPD稳定期患者的临床研究

Clinical Study of Liuwei Buqi Granules Combined with Seretide in the Treatment of Patients with COPD at Stable Stage

目的观察六味补气颗粒剂联合舒利迭对慢性阻塞性肺疾病稳定期(肺肾气虚证)患者的临床疗效。方法按照纳入和排除标准筛选的60例慢性阻塞性肺疾病稳定期(肺肾气虚证)患者随机分成对照组(30例)和观察组(30例)。对照组在西医常规对症治疗基础上给予舒利迭吸入剂治疗,观察组在对照组治疗基础上给予六味补气颗粒剂治疗,疗程均为8周,比较2组患者治疗前后的临床疗效、急性加重次数、CAT评分以及血清淀粉样蛋白A(SAA)水平等变化。结果临床疗效方面,观察组与对照组总有效率分别为93.33%和70.00%(P<0.01)。治疗后,观察组急性加重次数显著低于对照组(P<0.01)。2组患者治疗前后CAT评分、血清SAA水平比较均有显著下降(P<0.01);治疗后观察组咳痰、乏力、自汗等症状的改善明显优于对照组(P<0.05~0.01),CAT评分与对照组相比有一定差异(P<0.05),血清SAA水平显著低于对照组(P<0.01)。结论六味补气颗粒剂联合舒利迭可有效改善慢性阻塞性肺疾病稳定期(肺肾气虚证)患者的临床症状,减少急性加重次数,降低血清SAA水平,临床疗效满意。

OBJECTIVE To observe the clinical effect of Liuwe Buqi granule combined with Seretide on patients with chronic obstructive pulmonary disease(COPD)at stable stage(deficiency of lung and kidney qi).METHODS 60 patients with COPD at stable stage were randomly divided into control group(30 cases)and observation group(30 cases).The control group was treated with Seretide inhalation on the basis of routine western medicine treatment,and the observation group was treated with Liuwei Buqi granule on the basis of the control group for 8 weeks.The clinical efficacy and the change of acute exacerbation times,CAT score and serum amyloid A(SAA)level of the two groups were compared before and after treatment.RESULTS The total effective rates of observation group and control group were 93.33%and 70.00%(P<0.01),respectively.After treatment,the times of acute exacerbation in observation group was significantly lower than that in control group(P<0.01).The CAT score and the serum SAA level in the two groups were significantly decreased before and after treatment(P<0.01).After treatment,the improvement of expectoration,fatigue and self-sweating in observation group was better than that in control group(P<0.05,P<0.01).The CAT score in observation group was significantly different from that in control group(P<0.01).The serum SAA level in observation group was significantly lower than that in control group(P<0.01).CONCLUSION Liuwei Buqi granules combined with Seretide can effectively improve the clinical symptoms of patients with COPD at stable stage(deficiency of lung and kidney qi),reduce the times of acute exacerbation and reduce the level of serum SAA.The clinical curative effect is satisfactory.