白头翁汤灌肠治疗溃疡性结肠炎患者的疗效及对T细胞亚群的影响

Effect of Baitouweng Decoction Enema in the Treatment of Ulcerative Colitis Patients and Its Influence on T cell Subsets

目的观察白头翁汤灌肠治疗溃疡性结肠炎(UC)的疗效及对患者T细胞亚群的影响。方法将我院2014年1月-2018年3月收治的124例UC患者随机分为对照组和观察组,2组均给予美沙拉嗪治疗,观察组另给予白头翁汤灌肠治疗。30d后对比2组患者治疗有效率、肠镜评分、住院时间、UC活动度、T细胞亚群变化、不良反应发生率。结果治疗30d时,观察组治疗有效率(93.5%)明显高于对照组(72.6%),P<0.05;观察组住院时间明显低于对照组(P<0.05);观察组DAI评分明显低于对照组(P<0.05);2组外周血中CD3+与CD8+均出现下降趋势,而CD4+与CD4+/CD8+均出现上升趋势,且观察组变化幅度明显大于对照组(P<0.05);观察组不良反应发生率为9.7%,对照组不良反应发生率为8.1%,差异不明显(P>0.05)。结论白头翁汤灌肠能够有效提高UC疗效,降低患者UC活动指数及住院时间,同时改善患者免疫功能,值得临床进一步推广应用。

OBJECTIVE To investigate the efficacy of Baitouweng decoction enema in the treatment of ulcerative colitis patients and its effect on T cell subsets.METHODS 124 patients with ulcerative colitis admitted to our hospital from January2014 to March 2018 were randomly divided into control group and observation group.Both groups were given mesalazine and the observation group was additionally treated with Baitouweng decoction enema.The effectiveness rate of treatment,colonscopy score,length of stay,UC activity,T cell subsets change and the incidence of adverse reactions were compared between the two groups.RESULTS After 30 days of treatment,the effectiveness rate of treatment in observation group(93.5%)was significantly higher than that in control group(72.6%),P<0.05.The length of stay in observation group was significantly lower than that in control group(P<0.05).The DAI score in observation group was significantly lower than that in control group,P<0.05;The CD3+and CD8+in peripheral blood of both groups showed a downward trend while both CD4+and CD4+/CD8+showed an upward trend,and the change range of the observation group was significantly larger than that of the control group,P<0.05.The incidence of adverse reactions in observation group was 9.7%and the control group counterpart was 8.1%.The difference was not significant(P>0.05).CONCLUSION Baitouweng decoction enema can effectively improve the efficacy of UC,reduce the UC activity index and the length of stay,improve the immune function of patients,which is worthy of further promotion and application in clinical practice.