孕晚期B族链球菌感染差异及其对妊娠结局及新生儿的影响

Differences in group B streptococcal infections in late pregnancy and their effects on pregnancy outcomes and neonates

(1)目的分析在不同人群孕妇中孕晚期B族溶血性链球菌感染的差异,探讨B族链球菌感染对孕妇妊娠结局及新生儿结局的影响。(2)方法选取2017年1月～2018年5月在华北理工大学附属医院产检时发现B族溶血性链球菌感染并接受治疗的40例孕妇作为观察组,选取同期在我院分娩的40例未感染B族溶血性链球菌的产妇作为对照组,分析两组孕妇的一般情况、现有病史、分娩方式、妊娠结局,以及新生儿结局。两组胎盘均送病理检查。(3)结果观察组中有糖尿病家族史、妊娠期糖尿病、孕早期有上呼吸道感染病史者多于对照组,差异有统计学意义(P <0.05)。观察组剖宫产率高于对照组,差异有统计学意义(P <0.05)。观察组胎膜早破、羊水污染、早产、绒毛膜羊膜炎以及胎儿窘迫的发生率均高于对照组,差异有统计学意义(P <0.05);两组产妇是否为经产妇、孕早期是否保胎、甲状腺功能是否正常等一般情况,以及会阴侧切助产率、羊水污染、会阴裂伤发生率等比较,差异无统计学意义(P>0.05)。(4)结论妊娠期血糖异常以及有糖尿病家族史、孕早期有上感病史可能会增加B族链球菌感染率;B族溶血性链球菌感染可能增加孕妇和新生儿不良结局的发生率,对母婴造成严重危害。

Objective To analyze the differences of group B hemolytic streptococcus infection in pregnant women in different populations,and to explore the effect of group B streptococcal infection on pregnancy outcome and neonatal outcomes.Methods A total of 40 women with group B hemolytic streptococcus infection and treatment were selected as the observation group from January 2017 to May 2018 in the North China University of Science and Technology Affiliated Hospital.The other 40 patients who were selected as the control group.To analyzed the general condition,current medical history,mode of delivery,pregnancy outcome and neonatal outcomes of the two groups of pregnant women.Both groups of placenta were sent for pathological examination.Results There were more family history of diabetes,gestational diabetes mellitus,and a history of upper sensation in the early pregnancy than in the control group.The difference was statistically significant(P<0.05).The cesarean section rate of the observation group was higher than the control group,and the difference was statistically significant(P<0.05).The incidence of premature rupture of membranes,amniotic fluid contamination,premature delivery,chorioamnionitis,and incidence of fetal distress were higher in the observation group than in the control group,and the difference was statistically significant(P<0.05).There were no significant differences in the general conditions such as whether the fetus was preserved in the first trimester,whether the thyroid function was normal,and the incidence of perineal cut-off,amniotic fluid contamination and perineal laceration.The difference was not statistically significant(P>0.05).Conclusion Pregnancy abnormal blood glucose and family history of diabetes in early pregnancy may increase the infection rate of group B streptococcus.Group B streptococcus infection may increase the incidence of adverse outcomes in pregnant women and neonates,maternal and child causes serious harm.