甘精胰岛素与阿卡波糖分别联合二甲双胍对2型糖尿病患者长期血糖控制对比分析

Comparative Analysis of Long-term Glycemic Control in Patients with Type 2 Diabetes Mellitus Treated with Insulin Glargine and Acarbose Combined with Metformin

目的评价甘精胰岛素与阿卡波糖分别联合二甲双胍对2型糖尿病患者长期血糖控制的效果。方法 86例2型糖尿病患者随机分为对照组(二甲双胍联合阿卡波糖)、研究组(二甲双胍联合甘精胰岛素),各43例。比较不同组别患者治疗前、治疗6个月后、12个月后两组血糖指标(FBG、2 h PBG、HbAlc)、氧化应激指标(MDA、SOD、GSH-PX)、血脂代谢指标(TC、TG、LDL-C)、血糖达标率及不良反应发生率。结果治疗6个月后、12个月后,研究组血糖指标FBG、2 h PBG、HbAlc水平均低于对照组(P <0.05);氧化应激指标SOD、GSH-PX水平明显高于对照组,MDA水平明显低于对照组(P <0.05);两组间血糖达标率及不良反应发生率比较无统计学意义(P>0.05)。结论二甲双胍联合甘精胰岛素治疗2型糖尿病的疗效确切,具有更好的长期预后。

Objective To evaluate the effect of insulin glargine and acarbose combined with metformin on long-term glycemic control in patients with type 2 diabetes.Methods 86 patients with type 2 diabetes were divided into control group(metformin combined with acarbose) and the research group(metformin combined with insulin glargine)randomly,43 cases each.Blood glucose levels(FBG,2 h PBG,HbAlc),oxidative stress(MDA,SOD,GSH-PX),and lipid metabolism indicators(TC,TG,LDL-C),blood glucose compliance rate and incidence of adverse reactions were compared between the two groups before treatment,6 months after treatment,and 12 months after treatment.Results After 6 months and 12 months of treatment,the blood glucose levels of FBG,2 h PBG and HbAlc in the study group were lower than those in the control group(P<0.05);the levels of SOD and GSH-PX were significantly higher than those in the control group;the level of MDA was significantly lower than that of the control group(P<0.05);and the blood glucose standard-reaching rate and the incidence of adverse reactions were not statistically significant(P>0.05).Conclusion Metformin combined with insulin glargine is effective in the treatment of type 2 diabetes with a better long-term prognosis