摘要
目的:探讨Pirh2和p27^(kip1)在皮肤恶性黑色素瘤组织中的表达及其相关性。方法:采用免疫组织化学方法检测Pirh2与p27^(kip1)分别在45例皮肤恶性黑色素瘤标本与20例正常皮肤标本组织中的表达情况。结果:45例皮肤恶性黑色素瘤中Pirh2的阳性表达率为68.89%(31/45),p27^(kip1)的阳性表达率为17.78%(8/45);20例正常皮肤组织中Pirh2的阳性表达率为0%,p27^(kip1)的阳性表达率为75.00%(15/20)。正常皮肤组与皮肤恶性黑色素瘤组间比较,Pirh2与p27^(kip1)的表达差异有统计学意义,且皮肤恶性黑色素瘤组的Pirh2与p27^(kip1)的表达呈负相关(P<0.01)。结论:Pirh2在皮肤恶性黑色素瘤组织中的表达增加,与p27Kip1的表达呈负相关,提示两者可能参与了皮肤黑色恶性素瘤的发生和发展。
Objective:To investigate the expression and correlation of Pirh2 and p27^kip1 in cutaneous malignant melanoma.Methods:45 cases of cutaneous malignant melanoma and 20 samples of normal skin were examined for the expression of Pirh2 and p27^kip1 by immunohistochemistry.Results:The expression rate of Pirh2 and p27^kip1 in 45 cases of cutaneous malignant melanoma was 68.89%(31/45)and 17.78%(8/45).The expression of Pirh2 and p27^kip1 in 20 normal skin tissues was 0%and 75.00%(15/20).There was a statistically significant difference in the expression of Pirh2 and p27^kip1 between the normal skin group and the cutaneous malignant melanoma group,and the expression of Pirh2 and p27^kip1 in the cutaneous malignant melanoma group was negatively correlated(P<0.01).Conclusion:Pirh2 expressed more in cutaneous malignant melanoma and negatively correlated with p27kip1 expression,suggesting that Pirh2 and p27kip1 may be involved in the development and progression of cutaneous malignant melanoma.
作者
花卉
程佳伟
顾丽群
任祺
朱周
谷丽
HUA Hui;CHENG Jiawei;GU Liqun;REN Qi;ZHU Zhou;GU Li(Department of Dermatology,the Third People′s Hospital of Nantong,Jiangsu Province,Nantong 226006;Department of Dermatology,the First People′s Hospital of Nantong,Jiangsu Province)
出处
《南通大学学报(医学版)》
2018年第6期417-420,共4页
Journal of Nantong University(Medical sciences)
基金
南通市科技计划项目(yyzl5013)