Pirh2和p27^(kip1)蛋白在皮肤恶性黑色素瘤中的表达及意义

Expression and significance of Pirh2 and p27^(kip1) in cutaneous malignant melanoma

目的:探讨Pirh2和p27^(kip1)在皮肤恶性黑色素瘤组织中的表达及其相关性。方法:采用免疫组织化学方法检测Pirh2与p27^(kip1)分别在45例皮肤恶性黑色素瘤标本与20例正常皮肤标本组织中的表达情况。结果:45例皮肤恶性黑色素瘤中Pirh2的阳性表达率为68.89%(31/45),p27^(kip1)的阳性表达率为17.78%(8/45);20例正常皮肤组织中Pirh2的阳性表达率为0%,p27^(kip1)的阳性表达率为75.00%(15/20)。正常皮肤组与皮肤恶性黑色素瘤组间比较,Pirh2与p27^(kip1)的表达差异有统计学意义,且皮肤恶性黑色素瘤组的Pirh2与p27^(kip1)的表达呈负相关(P<0.01)。结论:Pirh2在皮肤恶性黑色素瘤组织中的表达增加,与p27Kip1的表达呈负相关,提示两者可能参与了皮肤黑色恶性素瘤的发生和发展。

Objective:To investigate the expression and correlation of Pirh2 and p27^kip1 in cutaneous malignant melanoma.Methods:45 cases of cutaneous malignant melanoma and 20 samples of normal skin were examined for the expression of Pirh2 and p27^kip1 by immunohistochemistry.Results:The expression rate of Pirh2 and p27^kip1 in 45 cases of cutaneous malignant melanoma was 68.89%(31/45)and 17.78%(8/45).The expression of Pirh2 and p27^kip1 in 20 normal skin tissues was 0%and 75.00%(15/20).There was a statistically significant difference in the expression of Pirh2 and p27^kip1 between the normal skin group and the cutaneous malignant melanoma group,and the expression of Pirh2 and p27^kip1 in the cutaneous malignant melanoma group was negatively correlated(P<0.01).Conclusion:Pirh2 expressed more in cutaneous malignant melanoma and negatively correlated with p27kip1 expression,suggesting that Pirh2 and p27kip1 may be involved in the development and progression of cutaneous malignant melanoma.