妊娠期肝内胆汁淤积症的临床诊断和治疗进展

Progress in clinical diagnosis and treatment of intrahepatic cholestasis during pregnancy

妊娠期肝内胆汁淤积症是妊娠期特有的并发症,临床以不同程度的瘙痒症状及胆汁酸升高为主要特征,在我国四川及上海具有较高的发病率。此疾病是致使胎儿死亡的重要原因,且胎儿死亡风险和病情严重程度无关,临床难以预测。此外,临床对此病的致病机制尚未明确,难以采取有效的预防干预措施。因此,妊娠期肝内胆汁淤积症的尽早诊断和治疗对改善围产儿结局具有重要意义。本文对妊娠期肝内胆汁淤积症的临床表现、诊断方法及治疗方法进行综述,以为临床治疗提供指导。

Intrahepatic cholestasis of pregnancy is a unique complication during pregnancy.It is mainly characterized by various degrees of pruritus and elevated bile acids.It has a high incidence in Sichuan and Shanghai.This disease is an important cause of fetal death,and the risk of fetal death is independent of the severity of the disease,and it is difficult to predict in clinic.In addition,the pathogenesis of the disease in clinical disease is not yet clear,and it is difficult to take effective preventive interventions.Therefore,early diagnosis and treatment of intrahepatic cholestasis of pregnancy is of great significance for improving perinatal outcome.This article reviews the clinical manifestations,diagnosis methods and treatment methods of intrahepatic cholestasis during pregnancy to provide guidance for clinical treatment.