帕金森病与非器质性睡眠障碍患者睡眠、情感、认知比较分析

Comparative Analysis of Sleep,Emotion and Cognition in Patients with Parkinson's Disease and Non-organic Sleep Disorders

目的:比较分析帕金森病(病例组)与非器质性睡眠障碍患者(对照组)睡眠、情感、认知障碍的临床特征,为临床治疗提供理论依据。方法:采用匹兹堡睡眠质量指数(PSQI)、焦虑自评量表(SAS)、抑郁自评量表(SDS)及简易智能精神状态检查量表(MMSE)、蒙特利尔智能评价量表(MoCA),对病例组与对照组进行分析比较。结果:病例组睡眠障碍发生率为75%,PSQI得分高,睡眠障碍因子分值高,睡眠药物因子分值低,与对照组比较,差异有统计学意义(P<0.01)。病例组SAS、MMSE及MoCA评分低于对照组,SDS评分高于对照组,差异有统计学意义(P<0.01)。结论:PD患者睡眠障碍发生率高,常合并抑郁及认知障碍;非器质性睡眠障碍患者常合并焦虑障碍,无明显认知障碍。

Objective:To compare the clinical features of sleeping,affective disorder and cognitive impairment between Parkinson's patients(case group) and non-organic sleep disorder patients(control group) for providing theoretical basis of clinical treatment.Method:Using the Pittsburgh Sleep Quality Index(PSQI),Self-rating Anxiety Scale(SAS),Self-rating Depression Scale(SDS),the Simple Intelligence Mental Status Examination Scale (MMSE),and the Montreal Smart Assessment Scale(MoCA) to compare the difference between the case group and control group.Result:In the case group,the incidence of sleep disorders was 75%,and the scores of PSQI,the sleep disorder factor and SDS were higher,while the score of sleep drug factor,SAS,MMSE and MoCA were lower than the control group,and the difference was statistically significant(P<0.01).Conclusion:PD patients have a higher incidence of sleep disorders,often associated with depression and cognitive impairment.While non organic sleep disorders patients often suffer from anxiety disorders but without obvious cognitive impairment.