喉癌患者肿瘤组织中PINCH1表达水平与患者临床预后的关系

Relationship between PINCH1 expression and prognosis in patients with laryngocarcinoma

目的探讨喉癌患者肿瘤组织中PINCH1表达水平与患者临床预后的关系。方法选择2009年1月～2013年12月在陕西中医药大学附属第二医院接受治疗的86例喉癌患者作为研究对象。根据喉癌肿瘤组织中PINCH1表达水平将患者分为PINCH1阳性表达组(n=45)和PINCH1阴性表达组(n=41)。另外选择同一患者癌旁正常组织作为对照(n=86)。比较PINCH1在喉癌组织及癌旁正常组织中的表达差异。分析肿瘤组织中PINCH1表达水平与患者临床病理特征的关系。采用Kaplan-Meier法绘制不同组别患者生存曲线,并应用Log-rank法进行比较。采用Cox比例风险回归分析影响患者预后的危险因素。结果 PINCH1在喉癌组织中的阳性表达率为52. 33%(45/86),显著高于癌旁正常组织阳性表达率8. 14%(7/86,P <0. 05)。PINCH1在喉癌患者肿瘤组织中的表达水平与性别、吸烟史、嗜酒史、分化程度、肿瘤部位无关(P> 0. 05),与年龄、临床分期、T分期、淋巴结转移显著相关(P <0. 05)。PINCH1阳性表达的喉癌患者5年总生存率显著低于PINCH1阴性表达的喉癌患者(P <0. 05)。临床分期(Ⅲ～Ⅳ期)、T分期(T3～T4期)、PINCH1表达水平(阳性)是影响喉癌患者预后的危险因素(P <0. 05)。结论喉癌患者肿瘤组织中PINCH1表达水平升高,可作为预测患者预后的指标。

Objective To investigate the relationship between PINCH1 expression and prognosis in patients with laryngocarcinoma. Methods Eighty-six patients with laryngocarcinoma who had received treatment in the Second Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine from Jan. 2009 to Dec. 2013 were selected as the study subjects. According to the expression levels of PINCH1 in tumor tissues,the patients were divided into PINCH1 positive expression group( n = 45) and PINCH1 negative expression group( n = 41). Normal tissues adjacent to the tumor were selected as the control group( n = 86). The expressions of PINCH1 between laryngocarcinoma and the adjacent normal tissues were compared. The relationship between the expression of PINCH1 in the tumor tissues and the clinicopathological features of the patients were analyzed. The survival curves of the two groups were plotted by KaplanMeier,and the Log-rank method was used to compare them. Cox proportional hazards regression analysis was used to analyze the risk factors influencing the prognosis of patients. Results The positive expression rate of PINCH1 in laryngocarcinoma tissues was 52. 33%( 45/86),which was significantly higher than that in the adjacent normal tissues of8. 14%( 7/86,P < 0. 05). The expression levels of PINCH1 in the tumor tissues was not related to sex,smoking history,alcohol history,differentiation or tumor location( P > 0. 05),but it was significantly related to age,clinical stage,T staging and lymph node metastasis( P < 0. 05). The 5-year survival rate of PINCH1 positive laryngocarcinoma patients was significantly lower than that of PINCH1 negative laryngocarcinoma patients( P < 0. 05). The clinic stage( stage Ⅲ ～Ⅳ),T stage( T3 ～ T4 stage) and PINCH1 expression levels( positive) were the risk factors for the prognosis of laryngocarcinoma( P < 0. 05). Conclusions The expression level of PINCH1 in tumor tissue can be used as a prognostic indicator for laryngocarcinoma.