血瘀体质多囊卵巢综合征患者的临床特征分析

Clinical characteristics of polycystic ovary syndrome with blood stagnation constitution in the patients

目的探讨血瘀体质多囊卵巢综合征患者的临床特征。方法收集多囊卵巢综合征患者504例,其中血瘀体质184例,倾向血瘀体质107例,非血瘀体质213例,分析、比较各组的人体测量学指标、激素水平和糖脂代谢指标。结果 (1)各组间年龄、初潮年龄、收缩压、舒张压、体重指数(BMI)、腰围、臀围、腰臀比(WHR)差异无统计学意义(P> 0. 05);(2)各组间促卵泡生成素(FSH)、促黄体生成素(LH)、LH/FSH、泌乳素(PRL)、雌二醇(E2)、雄烯二酮(AND)、性激素结合球蛋白(SHBG)差异无统计学意义(P> 0. 05),但血瘀体质组患者的睾酮(T)水平显著高于非血瘀体质组,差异有统计学意义(P <0. 05),血瘀体质组和倾向血瘀体质组的硫酸脱氢表雄酮(DHEAS)水平显著高于非血瘀体质组,差异有统计学意义(P <0. 05);(3)各组间空腹血糖(FPG)、空腹胰岛素水平(FINS)、胰岛素抵抗指数(HOMA-IR)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL-C)、载脂蛋白B(APO-B)、APO-B/载脂蛋白A(APO-A)差异无统计学意义(P> 0. 05),但血瘀体质组和倾向血瘀体质组患者的HDL-C、APO-A水平显著低于非血瘀体质组,差异有统计学意义(P <0. 05)。结论血瘀体质较非血瘀体质存在更严重的代谢紊乱问题,应根据血瘀体质的特点进行个体化治疗。

Objective To explore the clinical characteristics of polycystic ovary syndrome(PCOS) with blood stagnation constitution in the patients. Methods A total of 504 patients of PCOS were collected. Of them,184 cases were of blood stagnation constitution,107 cases were in the tendency of blood stagnation constitution and 213 cases without blood stagnation constitution. The anthropometric indicators,hormone levels and glucolipid metabolism indicators were analyzed and compared among the groups. Results 1. There were no differences in age,the age of menarche,systolic pressure,diastolic pressure,BMI,waist circumference(WC),hip circumference(HC) and the ratio of WC to HC among the groups(P >0. 05). 2. There were no differences in FSH,LH,LH/FSH,PRL,E2,AND and SHBG among the groups(P > 0. 05). The level of testosterone(T) in the blood stagnation constitution group was higher significantly than the level in the group without blood stagnation constitution(P < 0. 05). The levels of DHEAS in the group of blood stagnation constitution and the group with the tendency of blood stagnation constitution were higher significantly than the group without blood stagnation constitution(P > 0. 05). 3. There were no differences in FPG,FINS,HOMA-IR,TG,TC,LDL-C,APO-B and APO-B/APO-A among the groups(P > 0. 05). The levels of HDL-C and APO-A in the group with blood stagnation constitution and the group with the tendency of blood stagnation constitution were lower significantly than the group without blood stagnation constitution(P > 0. 05). Conclusion Compared with the patients without blood stagnation constitution,the metabolic disturbance is more serious in the patients with blood stagnation constitution. Hence,the treatment should be provided individually on the base of the characteristics of blood stagnation constitution.