加味参苓白术散对溃疡性结肠炎患者血清SOD、MDA水平的影响

Effect of Shenling Baizhu Powder on Ulcerative Colitis Patients Serum SOD and MDA

目的观察加味参苓白术散对溃疡性结肠炎患者血清SOD、MDA水平的影响。方法选择94例溃疡性结肠炎患者,将其随机分为观察组49例、对照组45例,对照组给予美沙拉秦治疗,观察组联合给予加味参苓白术散,2组均治疗6个月,随访6个月。比较2组患者临床疗效、血清SOD和MDA变化情况、血清CRP变化情况、随访复发率。结果观察组临床疗效优于对照组(P<0.05)。治疗后患者血清SOD明显升高、MDA明显降低(P<0.05),且观察组SOD高于对照组、MDA低于对照组(P<0.05)。治疗后2组血清CRP显著降低(P<0.05),且观察组低于对照组(P<0.05)。观察组随访复发率显著低于对照组(P<0.05)。结论加味参苓白术散联合美沙拉秦缓释颗粒剂治疗溃疡性结肠炎具有着显著的临床疗效,同时可有效降低患者治疗后复发率,其作用机制可能与清除机体氧自由基以及减轻机体炎症反应有关,值得临床推广。

Objective Analysis on the effect of Shenling Baizhu powder on ulcerative colitis patients serum SOD and MDA levels.Methods 94 cases of ulcerative colitis patients in our hospital,were randomly divided into the observation group of 49 cases,45 cases in the control group,the control group was given the salad Qin granule treatment,the observation group in the control group were given with modified shenglingbaizhusan,two groups were treated for 6 months,followed up for 6 months.The clinical efficacy of the two groups,the changes of serum SOD and MDA,the change of serum CRP,and the recurrence rate of follow-up were compared.Results The clinical effect of the observation group was significantly better than that of the control group(P<0.05).After treatment,serum SOD increased significantly and MDA decreased significantly in two groups(P<0.05).After treatment,SOD in observation group was higher than that in control group and MDA was lower than that in control group(P<0.05).After treatment,the serum CRP decreased significantly in the two groups(P<0.05),and the observation group was lower than that of the control group(P<0.05).The recurrence rate of the patients in the observation group was significantly lower than that of the control group(P<0.05).Conclusion Modified SHENLINGBAISHU Mesalazine SR Granules combined treatment of ulcerative colitis has significant clinical efficacy,and can effectively reduce the recurrence rate of the patients after treatment,the mechanism may be related to scavenging oxygen free radicals and reduce the inflammatory reaction,which is worthy of clinical promotion.