利培酮联合抗抑郁药对双相抑郁发作患者疗效的影响

Influence of risperidone combined with antidepressants on the efficacy of patients with bipolar depressive episode

目的探讨利培酮联合抗抑郁药治疗双相抑郁发作患者的临床疗效。方法 90例双相抑郁发作患者,按照随机数字表法分为观察组与对照组,各45例。对照组采用丙戊酸钠、舍曲林治疗,观察组在对照组治疗的基础上加用利培酮治疗。观察比较两组患者的临床疗效及不同时间段抑郁评分改善情况。结果治疗4、6周,观察组患者抑郁评分(12.11±2.68)、(6.50±1.75)分显著低于对照组的(16.07±3.46)、(10.09±2.24)分,差异有统计学意义(P<0.05)。观察组患者总有效率97.78%显著高于对照组的86.67%,差异有统计学意义(P<0.05)。结论针对双相抑郁发作患者采用利培酮联合丙戊酸钠、舍曲林治疗,可显著提高治疗效果,改善患者抑郁状态,具有较高的临床推广价值。

Objective To discuss the clinical efficacy of risperidone combined with antidepressants on the treatment of patients with bipolar depressive episode. Methods A total of 90 patients with bipolar depressive episodes were divided by random number table into observation group and control group, with 45 cases in each group. The control group was treated with sodium valproate and sertraline, and the observation group was treated with risperidone on the basis of the control group. The clinical efficacy and improvement of depression score at different time points was observed and compared between the two groups. Results After 4 and 6 weeks of treatment, the observation group had significantly lower depression score as(12.11±2.68) and(6.50±1.75) points than(16.07±3.46) and(10.09±2.24) points in the control group, and their difference was statistically significant(P<0.05). The observation group had significantly higher total effective rate as 97.78% than 86.67% in the control group, and the difference was statistically significant(P<0.05). Conclusion Combination of risperidone and with sodium valproate and sertraline can significantly improve the treatment effect of patients with bipolar depressive episode, and improve their depressive state. This method has a high clinical promotion value.