孟鲁斯特钠联合布地奈德治疗儿童过敏性鼻炎的观察

Effect of montelukast sodium combined with budesonide in the treatment of children with allergic rhinitis

目的 :探讨孟鲁斯特钠联合布地奈德治疗儿童过敏性鼻炎的效果。方法 :选取90例儿童过敏性鼻炎患儿,采取随机数字表法分为对照组和观察组各45例。对照组给予布地奈德治疗,观察组则给予布地奈德联合孟鲁斯特钠治疗。比较两组儿童过敏性鼻炎控制率;流涕、鼻痒、鼻塞和喷嚏消失时间;治疗前后促炎因子水平;药物不良反应发生率。结果:观察组儿童过敏性鼻炎控制率高于对照组,流涕、鼻痒、鼻塞和喷嚏消失时间短于对照组,促炎因子水平优于对照组(P<0.05)。两组药物不良反应发生率无明显差异(P> 0.05)。结论 :布地奈德联合孟鲁斯特钠治疗儿童过敏性鼻炎的应用效果确切,可有效改善促炎因子水平,且无严重不良反应。

Objective:To investigate the effect of montelukast sodium combined with budesonide in the treatment of children with allergic rhinitis.Methods:Ninety children with allergic rhinitis were enrolled and randomly divided into a control group(treated with budesonide)and an observation group(treated with both montelukast sodium and budesonide)with 45 cases each.The control rate of allergic rhinitis,the time for the disappearance of salivation,nasal itching,nasal congestion and sneezing,the level of pro-inflammatory factors before and after treatment and the incidence of adverse drug reactions were compared between the two groups.Results:The control rate of allergic rhinitis was higher,the time for the disappearance of salivation,nasal itching,nasal congestion and sneezing was shorter and the pro-inflammatory factor level was better in the observation group than the control group(P<0.05).There were no significant differences in the incidence of adverse drug reactions between the two groups(P>0.05).Conclusion:The application of budesonide combined with montelukast sodium in the treatment of children with allergic rhinitis is effective,can effectively improve the level of pro-inflammatory factors without serious adverse reactions.