沙利度胺在侵袭性非霍奇金淋巴瘤中的治疗作用及不良反应

Study the therapeutic effect and adverse reactions of Thalidomide in invasive non-hodgkins' lymphoma

目的探究沙利度胺在侵袭性非霍奇金淋巴瘤中的治疗作用及不良反应。方法采用随机数字表法将2017年2月～2018年2月收治的180例侵袭性非霍奇金淋巴瘤患者分成治疗组与对照组各90例,治疗组采用沙利度胺+常规化疗,对照组采用常规化疗。比较两组的治疗效果和不良反应。结果治疗组总有效率(61.11%)显著高于对照组(34.44%)(P <0.05);在Ⅰ～Ⅳ度的各类不良反应方面,治疗组发生率均显著低于对照组(P <0.05)。结论将沙利度胺应用于侵袭性非霍奇金淋巴瘤治疗中时,患者不良反应小,症状轻,且疗效显著。

Objective To study the therapeutic effect and adverse reactions of Thalidomide in invasive non-hodgkins’ lymphoma(NHL).Methods 180 invasive NHL patients treated from February 2017 to February 2018 in our hospital were randomly assigned to two groups,90 cases in each group.Therapy group took Thalidomide plus conventional chemotherapy;control group took the conventional chemotherapy.The therapeutic effect and adverse reactions were probed.Results The total effective rate in therapy group(61.11%) was statistically higher than control group(34.44%)(P<0.05);The incidence of adverse reactions of Ⅰ to Ⅳ in the treatment group was significantly lower than that in the control group,there was statistical difference(P<0.05).Conclusion Thalidomide can reduce the adverse event rate,relieve the clinical symptoms and increase the therapeutic effect.It is worthy of clinical application and promotion.