家庭雾化吸入布地奈德和复方异丙托溴铵治疗毛细支气管炎临床研究及成本分析

A cost analysis and clinical study of treating bronchiolitis by inhalation of budesonide and compound isopropyl bromide in family

目的:探讨家庭雾化吸入布地奈德和复方异丙托溴铵治疗轻、中度毛细支气管炎的疗效。方法:采取随机对照方法,将208例毛细支气管炎患儿分成家庭组和对照组。家庭组106例,在家庭雾化吸入布地奈德和复方异丙托溴铵;对照组102例,在医药门诊雾化室治疗,雾化吸入布地奈德和复方异丙托溴铵。疗程均为7天,观察两组临床症状、体征改善情况并对比其疗效和经济成本。结果:疗效比较,家庭组总有效率为99.1%,对照组总有效率为99.0%;家庭组与对照组主要症状与体征比较,经统计学处理,差异均无统计学意义(P> 0.05);成本分析:家庭组平均每例患儿比对照组少花费1328元。经统计学处理,差异均有统计学意义(P <0.01)。结论:家庭雾化吸入布地奈德和复方异丙托溴铵的混合液,能充分、快速、有效地发挥解痉、抗炎作用,对治疗小儿毛细支气管炎具有见效快、操作简便、痛苦少及不良反应小等优点,且疗效确切,社会及经济效益好。

Objective:To explore the effect of inhaled budesonide and compound isopropyl bromide in family on mild,moderate bronchiolitis.Methods:208 cases were divided into the family group and control group according to randomized controlled trial.106 cases in the family group were given inhalation of budesonide and compound isopropyl bromide in family.102 cases in the control group were given inhalation of budesonide and compound isopropyl bromide in medical clinic spray chamber,for 7 days.The clinical symptoms,signs of improvement,effects and cost were observed in two groups.Results:The total efficiency in the family group was 99.1%and 99.0%in the control group.There did not show statistically significant difference in symptoms and signs between two groups(P>0.05).In the family group,the average child spent less than 1328 yuan in the control group,with a statistically significant difference(P<0.01).Conclusions:The mixture of inhaled budesonide and compound isopropyl bromide in family can fully,fast,effectively exert the effects of antispasmodic and anti-inflammatory,with the advantages of quick effect,simple operation,less pain and less adverse reactions,show a exact effect,with good social and economic benefits.