3D生物打印支架的微孔结构与孔隙率的研究进展

Research progress in microporous structure and poroisity of 3D bio-printing scaffolds

近年来,3D生物打印受到越来越多研究者的关注,该技术弥补了传统组织工程技术的局限性,它可打印出精准、个性化的支架结构,并可以任意地设计形状、尺寸、孔的结构和孔隙率等。3D生物打印支架在组织工程应用中通常提供结构支撑和适宜的微环境以支持细胞行为,而支架的微孔结构及孔隙率对细胞的行为和健康至关重要,所以3D生物打印支架应该是具有高度多孔和互连的孔网络结构,以促进营养运输、废物排泄和细胞生长增殖分化。本文将综述从无生命到有生命的3D生物打印支架材料和打印方式,以及着重介绍支架的微孔结构及孔隙率相关研究。

In recent years,3D bio-printing has attracted more and more attention from researchers.This technology makes up for the limitations of traditional tissue engineering technology.It can print out accurate and personalized scaffold structure,and can design shape,size,pore structure and porosity at etc.The 3D bio-printing scaffold usually provides structural support and suitable microenvironment to support cell behavior in tissue engineering.The microporous structure and porosity of the scaffold are essential to the behavior and health of the cells.Therefore,the 3D bio-printing scaffolds should be highly porous and interconnected pore networks to facilitate nutrient transportation,waste excretion,and cell growths proliferation and differentiation.This paper reviewed the materials and printing methods of 3D bio-printing scaffolds from inanimate to life,and focued on the study of the microporous structure and porosity of the scaffolds.