骨化三醇联合碳酸司维拉姆治疗终末期肾脏病合并甲状旁腺功能亢进症患者的效果及对hs-CRP、FGF-23水平的影响

Effect of Rocalirol Combined with Sevelamer Carbonate on Patients with End-stage Renal Disease Complicated with Hyperparathyroidism and the Effect on the Levels of hs-CRP and FGF-23

目的:探讨骨化三醇联合碳酸司维拉姆治疗终末期肾脏病合并甲状旁腺功能亢进症(SHPT)患者的效果及对患者超敏C反应蛋白(hs-CRP)、成纤维细胞生长因子-23(FGF-23)水平的影响。方法:选取2016年2月-2018年1月本院收治的终末期肾脏病合并SHPT患者80例。按照随机数字表法将其分为观察组和对照组,各40例。对照组在基础治疗上联合碳酸钙D治疗,观察组在对照组基础上联合盐酸司维拉姆治疗。比较两组治疗前后甲状旁腺激素(iPTH)、血磷、hs-CRP和FGF-23水平。结果:治疗后,观察组iPTH、血磷水平均低于对照组,比较差异均有统计学意义(P<0.05);治疗后,观察组hs-CRP和FGF-23水平均低于对照组,比较差异均有统计学意义(P<0.05)。结论:骨化三醇联合碳酸司维拉姆治疗终末期肾脏病合并SHPT患者效果显著,可有效减轻肾脏炎性反应,调节甲状旁腺功能,值得推广。

Objective:To investigate the effect of Rocalirol combined with Sevelamer Carbonate on patients with end-stage renal disease complicated with hyperparathyroidism(SHPT)and the effect on levels of hypersensitive C reactive protein(hs-CRP)and fibroblast growth factor-23(FGF-23).Method:80 patients with end-stage renal disease complicated with SHPT in our hospital from February 2016 to January 2018 were selected.According to the random number table method,they were divided into observation group and control group,40 cases in each group.The control group was treated with Calcium Carbonate D on the basic treatment,while observation group was treated with Sevelamer Carbonate on the basis of control group.The levels of parathyroid hormone(iPTH),blood phosphorus,hs-CRP and FGF-23 before and after treatment between two groups were compared.Result:After treatment,the levels of iPTH and blood phosphorus in observation group were lower than those of control group,the differences were statistically significant(P<0.05).After treatment,the levels of hs-CRP and FGF-23 in observation group were lower than those of control group,the differences were statistically significant(P<0.05).Conclusion:Rocalirol combined with Sevelamer Carbonate on patients with end-stage renal disease complicated with SHPT has a significant effect,which can effectively alleviate the inflammatory reaction of the kidney and regulate the function of parathyroid gland,it is worth promoting.