颈动脉稳定与不稳定斑块急性脑卒中患者血浆UA、Lp-PLA2、D-D、Hcy及Fbg的变化观察

Observation on the Change of Plasma UA,Lp-PLA2,D-D,Hcy and Fbg in the Patients with Carotid Artery Stable and Unstable Plaque of Acute Stroke

目的:观察颈动脉稳定与不稳定斑块急性脑卒中患者血浆尿酸(UA)、脂蛋白相关磷脂酶A2(Lp-PLA2)、D-二聚体(D-D)、同型半胱氨酸(Hcy)及血纤蛋白原(Fbg)的变化情况。方法:选取2017年7月-2018年4月本院收治的36例颈动脉不稳定斑块急性脑卒中患者为观察组,同时期的36例颈动脉稳定斑块急性脑卒中患者为对照组。检测并比较两组UA、Lp-PLA2、D-D、Hcy及Fbg表达水平,两组中不同中国卒中量表评估结果及斑块指数者的表达水平。结果:观察组血浆UA、Lp-PLA2、D-D、Hcy及Fbg表达水平均显著高于对照组(P<0.05),且观察组中不同中国卒中量表评估结果及斑块指数者血浆UA、Lp-PLA2、D-D、Hcy及Fbg表达水平均高于对照组中相同评估结果及斑块指数者,比较差异均有统计学意义(P<0.05)。结论:颈动脉不稳定斑块急性脑卒中患者血浆UA、Lp-PLA2、D-D、Hcy及Fbg表达水平均高于颈动脉稳定斑块者,且不同中国卒中量表评估结果与斑块指数患者的差异明显,因此临床监测价值较高。

Objective:To observe the change situation of plasma uric acid(UA),lipoprotein-associated phospholipase A2(Lp-PLA2),D-dimer(D-D),homocysteine(Hcy)and fibrinogen(Fbg)in the patients with carotid artery stable and unstable plaque of acute stroke.Method:A total of 36 patients with carotid artery unstable plaque of acute stroke in our hospital from July 2017 to April 2018 were selected as observation group,36 patients with carotid artery stable plaque of acute stroke at the same time were selected as control group.The expression levels of plasma UA,Lp-PLA2,D-D,Hcy and Fbg of two groups were detected and compared,and the expression levels of two groups with different Chinese stroke scale evaluation results and plaque index were compared.Result:The expression levels of plasma UA,Lp-PLA2,D-D,Hcy and Fbg of observation group were significantly higher than those of control group,the differences were statistically significant(P<0.05),and the expression levels of plasma UA,Lp-PLA2,D-D,Hcy and Fbg in observation group with different Chinese stroke scale evaluation results and plaque index were higher than those of control group with same chinese stroke scale evaluation results and plaque index,the differences were statistically significant(P<0.05).Conclusion:The plasma UA,Lp-PLA2,D-D,Hcy and Fbg in the patients with carotid artery unstable plaque of acute stroke are significantly higher than those of patients with carotid artery stable plaque of acute stroke,and the differences of patients with different Chinese stroke scale evaluation results and plaque index are obvious,so its clinical monitoring value is higher.