鼓室注射甲泼尼龙琥珀酸钠治疗突发性耳聋的可行性

Feasibility of Injection of Methylprednisolone Sodium Succinate in Tympanic Cavity for Sudden Deafness

目的:探讨鼓室注射甲泼尼龙琥珀酸钠治疗突发性耳聋的可行性。方法:选择2016年1月-2017年12月于本院确诊单侧突发性耳聋的患者60例,按照随机数字表法将所有患者分为治疗组(n=33)和对照组(n=27)。治疗组给予患耳鼓室注射甲泼尼龙琥珀酸钠,对照组给予静脉注射甲泼尼龙琥珀酸钠,对比两组患者治疗有效率、治疗前后听力阈值升高平均值及症状改善情况、血脂水平及治疗过程中不良反应之间的差异。结果:治疗组治疗总有效率显著高于对照组(P<0.05);治疗组患者治疗后各频率下的听力上升平均值明显高于对照组(P<0.05);治疗组治疗后三组主要症状改善率显著高于对照组(P<0.05);治疗组治疗后总胆固醇、甘油三酯及脂蛋白A均显著低于对照组(P<0.05);两组患者治疗过程中均未出现明显不良反应。结论:鼓室注射注甲泼尼龙琥珀酸钠能更有效提升突发性耳聋患者的治疗效果,同时对患者血脂水平变化影响较小,安全性也较高。

Objective:To investigate the feasibility of tympanosin injection of methylprednisolone sodium succinate in the treatment of sudden deafness.Method:Sixty patients with unilateral sudden deafness diagnosed in our hospital from January 2016 to December 2017 were enrolled.All patients were divided into treatment group(n=33)and control group(n=27)according to random number table.The treatment group was given Methylprednisolone Sodium Succinate Injection in the ear chamber.The control group received intravenous injection of Methylprednisolone Sodium Succinate.The effective rate of treatment,the mean value of hearing threshold before and after treatment,and the improvement of symptoms,blood lipid levels and adverse reactions during treatment of two groups were compared.Result:The total effective rate of treatment group was significantly higher than that of the control group(P<0.05).The average hearing increase of the treatment group was significantly higher than that of the control group(P<0.05).The improvement rate of the main symptoms in the treatment group was significantly higher than that in the control group(P<0.05).The total cholesterol,triglyceride and lipoprotein A in the treatment group were significantly lower than those in the control group(P<0.05).There were no significant adverse reactions during the treatment of the two groups of patients(P>0.05).Conclusion:Intratympanic injection of Methylprednisolone Sodium Succinate can effectively improve the therapeutic effect of patients with sudden deafness.At the same time,it has little effect on the changes of blood lipid levels and safety.