天灸治疗精神分裂症患者血脂异常的临床观察

Clinical Observation on Dyslipidemia of Schizophrenia with Medicinal Vesiculation

目的:观察天灸治疗精神分裂症患者血脂异常的临床疗效。方法:本试验的100例患者均为本院住院的符合纳入标准的患者,随机分为试验组和对照组,每组各50例。试验组给予天灸治疗,对照组给予辛伐他汀口服治疗,两组疗程均为60 d。试验前后测定血脂四项(TC、TG、VDL-C、HDL-C)、肝功能(ALT、AST)、肾功能(Cr、Urea)、磷酸肌酸激酶(CK)及试验中出现肌痛、皮肤过敏情况及中医症候积分。结果:试验后两组TC、TG、LDL-C均较治疗前均有明显降低,比较差异有统计学意义(P<0.01);对照组降低的幅度更大,差异有统计学意义(P<0.05)。试验后试验组的HDL-C较试验前有明显的提高,差异有统计学意义(P<0.05);对照组HDL-C升高不明显,差异无统计学意义(P>0.05);两组试验后HDL-C比较差异有统计学意义(P<0.05)。试验组症候疗效总有效率为87.23%,对照组为58.69%,比较差异有统计学意义(P<0.01)。试验组仅出现皮肤局部过敏的一般不良反应,而对照组出现肝脏、肌肉毒性的不良反应,两组比较差异有统计学意义(P<0.05)。结论:天灸治疗精神分裂症患者血脂异常在全面改善血脂及缓解临床症状方面有肯定的作用,且安全性好,值得临床推广应用。

Objective:To explore the clinical efficacy of moxibustion in the treatment on dyslipidemia in patients with schizophrenia.Method:One hundred patients eligible for inclusion and meeting certain criterion were selected and randomly divided into two groups,experimental group and control group,50 cases in each group.The experimental group was treated with medicinal vesiculation,while the control group was treated with Simvastatin,both groups were treated of 60 d.Four items of blood lipid(TC,TG,VDL-C,HDL-C),liver function(ALT,AST),renal function(Cr,Urea),creatine phosphate kinase(CK),myalgia,skin allergy and scores of TCM were measured before and after the experiment.Result:After experiment,the levels of TC,TG and LDL-C in the two groups were significantly lower than those before treatment,the differences were statistically significant(P<0.01);the decrease in the control group was more significant(P<0.05).After experiment,the level of HDL-C in experimental group was significantly higher than that before the experiment(P<0.05),the level of HDL-C in the control group was not significantly increased,there was no significant difference(P>0.05);after experiment,the levels of HDL-C in the two groups had significant difference(P<0.05).The total effective rate was 87.23%in the experimental group and 58.69%in the control group,the differences were statistically significant(P<0.01).There were only general adverse reactions of local skin allergy in the experimental group,while there were adverse reactions of hepatotoxicity and muscular toxicity in the control group,the differences were statistically significant(P<0.05).Conclusion:Medicinal vesiculation has a positive effect on improving blood lipid and alleviating clinical symptoms in schizophrenia patients with dyslipidemia.It is safe and worthy of further clinical application.