血清前列腺特异性抗原联合血清肿瘤相关物质在早期前列腺癌诊断中的应用分析

Application of serum prostate specific antigen combined with serum tumor associated material in the early diagnosis of prostate cancer

目的分析血清前列腺特异性抗原(PSA)联合血清肿瘤相关物质(TAM)在早期诊断前列腺癌中的应用价值。方法选择128例前列腺癌患者为病例组,另选择128例前列腺良性病变者为对照组,检测所有患者PSA及TAM值,分析PSA联合TAM在早期诊断前列腺癌中的应用价值。结果以PSA≥4.08 ng/ml为诊断前列腺癌的临界值,PSA诊断前列腺癌的准确度、特异度以及灵敏度分别为82.8%、76.1%和88.6%,受试者工作特征(ROC)曲线下面积为0.873。以TAM≥98.36 U/ml为诊断前列腺癌的临界值,TAM诊断前列腺癌的准确度、特异度以及灵敏度分别为77.3%、78.7%和74.5%,ROC曲线下面积为0.832。实施双指标联合检测,特异度为96.6%,高于单一指标诊断特异度。病例组患者TAM和PSA水平均高于对照组,差异均有统计学意义(P﹤0.05)。结论在进行筛查以及早期诊断前列腺癌中,采用PSA及TAM联合检测法,可提升诊断特异度,令检查结果更为精准,值得进一步在临床中推广应用。

Objective To analyze the value of serum prostate specific antigen(PSA)combined with serum tumor associated material(TAM)in the early diagnosis of prostate cancer.Method 128 patients with prostate cancer were included as case group,while another 128 with benign prostate lesions were recruited as control,of which the PSA and TAM levels were detected to determine the diagnostic value of both measures in the early diagnosis of prostate cancer.Result With PSA≥4.08 ng/ml as the critical value for confirming prostate cancer,the accuracy,specificity and sensitivity of PSA in the diagnosis of prostate cancer were 82.8%,76.1%and 88.6%,respectively,and the area under the curve of receiver operating characteristic(ROC)curve was 0.873.With TAM≥98.36 U/ml as the critical value instead,the accuracy,specificity and sensitivity of TAM in the diagnosis of prostate cancer were 77.3%,78.7%and 74.5%,respectively,with AUC of ROC being 0.832.When combined,the coupled detection indicated a specificity as high as 96.6%,which was higher than that of each measure used alone.The levels of TAM and PSA in the case group were significantly higher than those in control group,demonstrating statistically significant difference(P<0.05).Conclusion In the screening and early diagnosis of prostate cancer,the combined detection of PSA and TAM can improve the diagnostic specificity and accuracy.