糖尿病前期患者前庭功能损伤及其影响因素分析

Analysis of vestibular function and risk factors in pre-diabetic mellitus patients

目的比较糖尿病前期患者与健康人群前庭温度试验的差异,了解糖尿病前期是否存在前庭功能受损,并探讨糖尿病前期前庭功能受损的影响因素。方法通过口服葡萄糖耐量试验连续入组糖尿病前期患者62例,男性30例,女性32例,平均年龄(52. 21±9. 78)岁,对照组选取同期年龄、性别构成接近的血糖结果正常的健康体检人群44例,男性19例,女性25例,平均年龄(49. 55±7. 20)岁。收集受试者身高、体质量等一般资料,进行内分泌相关检查及前庭温度试验,记录双眼慢相角速度。在糖尿病前期组中分析前庭功能损害的影响因素。结果糖尿病前期组44例(71. 0%)存在前庭功能损害,对照组为17例(38. 6%),差异有统计学意义(P=0. 001);与对照组比较,糖尿病前期组双眼慢相角速度下降,差异有统计学意义(右眼P=0. 026,左眼P=0. 016);在糖尿病前期组中,Logistic回归分析显示,随着年龄增大,糖化血红蛋白浓度升高,糖尿病前期患者出现前庭功能损害的危险性增大(年龄P=0. 013,糖化血红蛋白P=0. 040)。结论糖尿病前期患者前庭功能损害检出率高,表现为双侧受损。年龄、糖化血红蛋白是糖尿病前期前庭功能损害的可能危险因素。

Objective To compare the differences of vestibular function among the pre-diabetic patients and the controls and to analysis the characteristics and risk factors of vestibular dysfunction in pre-diabetic patients. Methods All participants underwent oral glucose tolerance test. Sixty-two pre-diabetic patients were enrolled with 44 age-and sex-matched controls. Weight,height,and other general information are collected in all subjects. Laboratory tests and vestibular caloric test were carried out. Slow phase velocity was collected. In pre-diabetic patients,the risk factors associated with vestibular dysfunction were analyzed. Results There were 44 cases with vestibular dysfunction in pre-diabetic patients,while 17 cases in the controls,with the statistically significant difference( P =0. 001). Compared with the controls,slow phase velocity decreased in both eyes in the pre-diabetic patients,with the statistically significant difference( P = 0. 026 for the right eyes and P = 0. 016 for the left eyes). Logistic regression analysis showed that as age and glycosylated hemoglobin A1c( HbA1c) increased,the pre-diabetic patients had an increased risk of vestibular dysfunction( age P =0. 013,HbA1c P = 0. 040). Conclusion The incidence of vestibular dysfunction is increased in the pre-diabetic patients. Age and HbA1c might be risk factors associated with vestibular dysfunction in the pre-diabetic patients.