摘要
从红曲色素中合成了3个衍生物,对不同的人癌细胞(SH-SY5Y、HepG2、HT-29、BGC-823、AGS和MKN45)的细胞毒性进行了评价。红斑素衍生物O1在受试化合物中显示出最大的抗癌作用。与紫杉醇相比,红斑素衍生物O1对人胃癌细胞SH-SY5Y、BGC-823、AGS和MKN45的生长抑制作用更强,同时,其对正常人胃上皮细胞GES-1的细胞毒性小于紫杉醇。在新的天然抗癌试剂的开发中,红斑素衍生物O1可以作为前体化合物提供。
Three derivatives were synthesized from monascus product.The cytotoxicity of the derivatives to various human cancer cells(SH-SY5Y,HepG2,HT-29,BGC-823,AGS,and MKN45)was evaluated.Rubropunctatin derivative O1 showed the greatest anticancer effect within the tested compounds.The inhibition effect of rubropunctatin was higher than that of taxol on the growth of the human gastric cancer cell SH-SY5Y,BGC-823,AGS,and MKN45.On the other hand,its cytotoxicity to the normal human gastric epithelial cell GES-1 was less than that of taxol.Rubropunctatin derivative O1 could be supplied as a precursor compound in the development of a new natural anticancer reagent.
作者
陈成群
熊倩
魏杰
CHEN Chengqun;XIONG Qian;WEI Jie(Department of Chemical Engineering,Fuzhou University Zhicheng College,Fuzhou 350001,China)
出处
《化工技术与开发》
CAS
2019年第1期9-12,共4页
Technology & Development of Chemical Industry
基金
福建省教育厅中青年项目(科技A)(JAT160655)
2018年国家级大学生创新创业训计划项目(201813470007)
关键词
红曲色素
抗癌
细胞凋亡
monascus pigments
anticancer
apoptosis
