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甘精胰岛素联合阿卡波糖治疗老年2型糖尿病鼻饲患者26例 被引量:5

Effect of insulin glargine combined with acarbose on 26 elderly patients with type 2 diabetes mellitus fed by nasal feeding
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摘要 脑血管病是老年糖尿病患者常见的大血管并发症,一部分脑血管病后遗症的老年2型糖尿病患者存在假性延髓性麻痹,需鼻饲饮食,但因其长期卧床,消化能力差,如一次大量进食往往会因返流误吸导致反复肺感染。临床上采用胃管鼻饲持续滴注肠内营养剂配合多次混合奶小量加餐的方法,在保证营养的基础上有效避免反复肺感染的发生。这种进食方法导致此类患者的血糖无法明确区分空腹及餐后,如应用降糖药或胰岛素不当一方面导致血糖控制差影响脑血管病的治疗效果,一方面极易出现低血糖。此类患者低血糖时往往无明显的交感神经兴奋的表现,且往往因脑血管病后遗症本身存在意识障碍,导致低血糖无法及时发现并得到处理,严重低血糖的影响往往是致命的^[1,2]。所以摸索一种有效、安全且方便的降糖方法具有非常现实的临床意义。我科2008年至2013年收治该类患者26名,应用甘精胰岛素配合阿卡波糖控制其血糖,效果好,安全性高,总结体会如下。
作者 王雁 WANG Yan
出处 《武警后勤学院学报(医学版)》 CAS 2018年第7期609-610,共2页 Journal of Logistics University of PAP(Medical Sciences)
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  • 1International Diabetes Federation. Diabetes Atlas (sixth edition). 2013.
  • 2IIag LL, Kerr L, Malone JK, et al. Prandial Premixed Insulin Analogue Regimens Versus Basal Insulin Analogue Regimens in the Management of Type 2 Diabetes: An Evident-based Comparison. Clin Ther, 2007, 29(6 pt1): 1254-1270.
  • 3Monami M, Marchionni N, Mannucci E. Long-acting insulin analogues versus NPH human insulin in type 2 diabetes: a meta-analysis. Diabetes Res Clin Pract, 2008, 81(2): 184-189.
  • 4Robbins DC, Beisswenger PJ, Ceriello A, et al. Mealtime 50/50 Basal + Prandial Insulin Analogue Mixture with a Basal Insulin Analogue, Both Plus Metformin, in the Achievement of Target HbA1c and Pre- and Postprandial Blood Glucose Levels in Patients with Type 2 Diabetes: A Multinational, 24-Week, Randomized, Open-Label, Parallel-Group Comparison. Clin Ther, 2007, 29(11): 2349-2364.
  • 5Kazda C, Hülstrunk H, Helsberg K, et al. Prandial insulin substitution with insulin lispro vs. basal therapy with insulin glargine: A randomized controlled trial in patients with type 2 diabetes beginning insulin therapy. J Diabetes Complications, 2006, 20(3): 145-152.
  • 6Rosenstock J, Ahmann AJ, Colon G, et al. Advancing insulin therapy in type 2 diabetes previously treated with glargine plus oral agents: prandial premixed (insulin lispro protamine suspension/lispro) versus basal/bolus (glargine/lispro) therapy. Diabetes Care, 2008, 31(1): 20-25.
  • 7Jain SM, Mao X, Escalante-Pulido M, et al. Prandial-basal insulin regimens plus oral antihyperglycaemic agents to improve mealtime glycaemia: initiate and progressively advance insulin therapy in type 2 diabetes. Diabetes Obes and Metab, 2010, 12(11): 967-975.
  • 8Buse JB, Wolffenbuttel BH, Herman WH, et al. DURAbility of basal versus lispro mix 75/25 insulin efficacy (DURABLE) trial 24-week results: safety and efficacy of insulin lispro mix 75/25 versus insulin glargine added to oral antihyperglycemic drugs in patients with type 2 diabetes. Diabetes Care, 2009, 32(6): 1007-1013.
  • 9Eli L. Pre-Mix Insulin Lispro Treatment for Type 2 Diabetes Who Consume a Light Breakfast. ClinicalTrials.gov[serial online] 2011 Nov 9 [cited 2013 Oct 24]. Available at: http://www.clinicaltrials.gov/ct2/show/results/NCT00664534?term=%E2%80%9Clispro%E2%80%9D+AND+%22glargine%22&rank=34§=Xd86015#outcome8.
  • 10Jacober SJ, Scism-Bacon JL, Zagar AJ. A comparison of intensive mixture therapy with basal insulin therapy in insulin-naive patients with type 2 diabetes receiving oral antidiabetes agents. Diabetes Obes Metab, 2006, 8(4): 448-455.

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