慢性阻塞性肺病患者肺功能与血清C反应蛋白的关系

Relationship between Lung Function and Serum C-reactive Protein in Patients with Chronic Obstructive Pulmonary Disease

目的探讨慢性阻塞性肺疾病患者肺功能情况与血清C反应蛋白的关系。方法选取2017年6月～2018年7月我院收治并规律随诊的慢性阻塞性肺病患者180例,分为稳定期(对照组)和急性加重期(观察组)两组,每组各90例。观察两组肺活量(VC)、第1秒用力呼气容积(FEV1)、残气量(RV)、肺总量(TLC)情况;两组与血清C反应蛋白的关系,同时分析慢性阻塞性肺病患者C反应蛋白与肺功能的相关性。结果观察组肺功能中的VC、FEV1、TLC较对照组明显下降(P <0.05)、RV及C反应蛋白较稳定组增高(P <0.05);肺功能中VC、FEV1、TLC与C反应蛋白呈负相关(P <0.05),RV与C反应蛋白呈正相关(P <0.05)。结论 C反应蛋白水平的高低能反映慢性阻塞性肺病患者的病情,可帮助判断预后和指导治疗。

Objective:To investigate the relationship between lung function and serum C-reactive protein in patients with chronic obstructive pulmonary disease (COPD).Methods:Totally,180 patients with COPD were admitted and treated in our hospital from June 20017 to May 2018.They were divided into control group (stationary)and test group (acute exacerbation)with 90 patients in each group.The VC,FEV1,RV,and TLC were compared between the two groups.The relationship between serum C-reactive protein and lung function was analyzed.Results:The VC,FEV1,TLC in test group were significantly lower than those in control group.There was a significant negative relation between VC,FEV1,TLC,and serum C-reactive protein.There was a significant positive between RV and serum C-reactive protein (P< 0.05).Conclusions:Serum C-reactive protein can reflect of the development of COPD and to help determine prognosis and guiding treatment.