非小细胞肺癌组织中VEGF和Endostatin的表达意义

Expression of VEGF and Endostatin in Non-small Cell Lung Cancer

目的探讨非小细胞肺癌组织中血管内皮生长因子(VEGF)和内皮抑素(endostatin)的表达意义。方法选取符合本次研究相关标准的非小细胞肺癌患者共189例。采用免疫组化法检测非小细胞肺癌癌组织中VEGF和endostatin水平,统计二者阳性率。将年龄、性别、发病部位、肿瘤直径、病理类型、TNM分期、淋巴结转移、微血管密度(MVD)作为可能影响治疗效果的因素纳入研究,先后进行单因素和先Cox多因素回归分析。结果 Endostatin阳性与肿瘤大小、淋巴结转移、MVD呈负相关; VEGF阳性与肿瘤大小、淋巴结转移、TNM分期、MVD呈正相关,P均<0.05。结论二者在肿瘤新生血管上有明显作用,通过观察Endostatin、VEGF水平及阳性表达情况可辅助非小细胞肺癌诊断、病情评估、预后评估,对临床治疗有指导意义。

Objective To analyze the expression of vascular endothelial growth factor(VEGF)and endostatin in non-small cell lung cancer. Methods A total of 189 patients with non-small cell lung cancer who met the criteria of this study were selected.The levels of VEGF and endostatin in non-small cell lung cancer tissues were detected by immunohistochemistry,and the positive rates of the two groups were counted.Age,gender,location,tumor size,pathological type,TNM staging,lymph node metastasis and microvessel density(MVD)as factors that may affect the treatment effect were included in the study,single factor and Cox multiple factor regression were analysed successively. Results Endostatin positive was negatively correlated with tumor size,lymph node metastasis and MVD;VEGF positive was positively correlated with tumor size,lymph node metastasis,TNM staging and MVD.P were both less than 0.05. Conclusion They both play an important role in tumor Neovascularization,and through the observation of Endostatin,VEGF level and positive expression,can help diagnosis,disease evaluation and prognosis evaluation of non-small cell lung cancera,there are guiding significance for clinical treatment.