帕罗西汀联合心理治疗对女性围绝经期情绪障碍、睡眠质量及血清性激素水平的影响

Effects of Paroxetine Combined with Psychotherapy on Emotional Disorder,Sleep Quality and Serum Sex Hormone Levels in Women during Perimenopausal Period

目的观察帕罗西汀联合心理治疗对女性围绝经期情绪障碍、睡眠质量及血清性激素水平的影响。方法回顾性分析2016年4月—2018年4月收治的门诊和住院围绝经期患者104例,按照治疗方式分为观察组和对照组,每组52例。观察组给予帕罗西汀联合心理治疗,对照组给予雌激素替代疗法联合心理治疗。持续治疗12周。比较2组情绪障碍、睡眠质量、血清性激素水平、围绝经期症状,并观察2组临床疗效及不良反应发生情况。结果治疗后,2组汉密顿焦虑量表(HAMA)、汉密顿抑郁量表(HAMD)评分均低于治疗前,且观察组HAMD评分低于对照组(P <0. 05)。2组匹兹堡睡眠质量指数(PSQI)评分均低于治疗前,且观察组低于对照组(P <0. 05)。2组血清促卵泡生成素(FSH)、促黄体生成素(LH)水平均低于治疗前,雌二醇(E2)水平高于治疗前(P <0. 05)。2组改良Kupperman评分低于治疗前,且观察组低于对照组(P <0. 05)。观察组总有效率高于对照组,不良反应量表评分低于对照组(P <0. 05)。结论帕罗西汀联合心理治疗用于女性围绝经期治疗中,可以减轻患者情绪障碍,提升睡眠质量,改善血清性激素水平,治疗效果显著,且安全性较高。

Objective To observe effects of Paroxetine combined with psychotherapy on emotional disorder,sleep quality and serum sex hormone levels in women during perimenopausal period.Methods A total of 104 women during perimenopausal period admitted during April 2016 and April 2018 were divided into observation group and control group(n=52 for each group)according to different therapeutic methods.Observation group was treated with Paroxetine combined with psychotherapy,while control group was treated with estrogen replacement therapy,and times of continuous treatments were 12 weeks.After treatment in two groups,values of emotional disorders,sleep quality,serum sex hormones levels and perimenopausal period symptoms were compared,and efficacy and incidence rate of adverse reactions were observed.Results After treatment,scores of Hamilton anxiety scale(HAMA)and Hamilton rating scale for depression(HAMD)were significantly higher than those before treatment in two groups,and HAMD score in observation group was significantly lower than that in control group(P<0.05);scores of Pittsburgh sleep quality index(PSQI)were significantly lower than those before treatment in two groups,and the score in observation group was significantly lower than that in control group(P<0.05);levels of follicle stimulating hormone(FSH)and luteinizing hormone(LH)were significantly lower,while estradiol(E2)levels were significantly higher than those before treatment in two groups(P<0.05);modified Kupperman scores were significantly lower than those before treatment,and the score in observation group was significantly lower than that in control group(P<0.05).In observation group,the total effective rate was significantly higher,while treatment emergent symptom scale(TESS)score was significantly lower than those in control group(P<0.05).Conclusion Paroxetine combined with psychotherapy in treatment of women during perimenopausal period may reduce emotional disorders,improve sleep quality and levels of serum sex hormones with good efficacy and safety.