辣椒素受体在精神分裂症中的研究进展

Research Progress of Capsaicin Receptors in Schizophrenia

精神分裂症是一种病因和病理机制尚未完全阐明的慢性重性精神疾病。抗精神病药物治疗是精神分裂症首选的治疗措施。目前的药物并不能显著改善患者的认知功能及临床结局,且不良反应明显,故新药靶点的开发变得日趋迫切。近年来,许多组织学、遗传学、药理学等方面的研究证据证实辣椒素受体参与调节大脑的神经元活动,与焦虑、抑郁及精神分裂症等疾病具有相关性。虽然目前辣椒素受体在精神分裂症中的研究尚处于初级阶段,但该受体与中枢多巴胺受体及大麻素受体系统等联系紧密,很可能成为一个非常有潜力的治疗靶点。

Schizophrenia is a severe chronic mental disease with etiology and pathological mechanism to be further elucidated.Antipsychotic drugs are the first line treatment of schizophrenia,but the existing drugs have not been proven to significantly improve the patients′cognitive function and clinical outcome,and the adverse effects are obvious,therefore developing new drug targets has become increasingly urgent.In recent years,many studies on histology,genetics and pharmacology have confirmed that capsaicin receptors are involved in the regulation of neuronal activity in the brain and are associated with anxiety,depression,schizophrenia and other diseases.Although the study of capsaicin receptor in schizophrenia is still in its infancy,capsaicin receptor is closely related to central dopamine receptor and cannabinoid receptor system,therefore it is likely to be a potential therapeutic target.