岩藻糖基转移酶的研究进展

Progress in Study of Fucosyltransferase

岩藻糖基转移酶(FucT)是一类生物合成酶,参与岩藻化寡糖合成,催化L-岩藻糖从供体底物鸟苷二磷酸β-L-岩藻糖转移到各种糖受体底物,包括低聚糖、糖蛋白和糖脂,岩藻糖基化通常是寡糖和糖结合物生物合成的最后一步。含有L-岩藻糖的糖结合物对大量的生理和病理活动是必不可少的,如炎症、细菌和病毒感染、肿瘤转移和遗传紊乱。FucTs在肝癌、肺癌、卵巢癌、结肠癌等肿瘤中高表达,可能参与肿瘤转移过程,并在气道黏膜修复中起重要作用,参与胚胎着床等过程。

Fucosyltransferase(FucT)is a kind of biosynthesis enzyme,which participates in the synthesis of fucoidated oligosaccharides,catalyzes the transformation of L-fucose from donor substrate guanosine diphosphateβ-L-fucose to various glucose receptor substrates,including oligosaccharides,glycoproteins and lipids,and fucosylation is usually the last step in biosynthesis of oligosaccharides and glycoconjugates.Sugar conjugates containing L-fucose are essential for a large number of physiological and pathological activities,such as inflammation,bacterial and viral infections,tumor metastasis and genetic disorders.FucT is highly expressed in liver cancer,lung cancer,ovarian cancer,colon cancer and other tumors,and it may be involved in the process of tumor metastasis,play an important role in airway mucosal repair,and participate in the process of embryo implantation.