功能磁共振成像在偏头痛患者中的研究进展

Advances in Research of Functional Magnetic Resonance Imaging in Migraine Patients

偏头痛被列为最严重的慢性功能障碍性疾病之一,长期反复发作其累积效应可引起进行性脑功能障碍。功能磁共振成像(f MRI)因具有高空间分辨率的特点被广泛应用于评估偏头痛患者认知功能。偏头痛患者脑功能可通过f MRI局部脑血流量间接反映出来,在偏头痛患者发作期或发作间期均存在相应脑区的活化或抑制。在皮质区已发现,偏头痛患者颞叶区域较正常人呈现出明显的活化。就基底核区域而言,基底核的活动随着偏头痛发作次数的增加而降低,其中尾状核、壳核和苍白球区域对外界疼痛刺激表现出功能活性减低。此外,就神经网络而言,默认网络子系统属于疼痛连接体,偏头痛患者默认网络核心区域之间的功能连接程度降低,而默认网络与突显网络之间连接程度增加,以此来转移头痛带来的不愉快感觉。

Migraine is one of the most severe chronic neurovascular diseases,and the long-term repeated attacks can cause progressive brain dysfunction.The functional magnetic resonance imaging(fMRI)has already been widely used to evaluate the cognitive function of migraine patients due to its high spatial resolution.As for migraine sufferers,their brain function can be reflected indirectly by the fMRI local cerebral blood flow,and there is an activation or inhibition in the corresponding brain region in their attack stage or interictal stage.It has been found that in the cortical area the temporal region of migraine sufferers has significant activation compared with normal people.In the basal ganglia,the activity of the basal ganglia decreases as the increase of migraine attacks,while the caudate nucleus,putamen nucleus and globus pallidus show the reduced functional activity to the external pain and stimulus.In addition,in terms of neural networks,the default network subsystem is a part of the pain connecter,and the default network core zones of migraine sufferers have reduced functional connectivity,while the connectivity between the default network and the highlighted network increases,so as to divert the unpleasant feeling derived from headache.