抑癌基因PDCD4在子宫内膜异位症中的作用及其机制

Role of Suppressor PDCD4 in Endometriosis and Its Mechanism

子宫内膜异位症(EMs)属于子宫内膜异位性疾病,是子宫内膜组织出现在子宫以外的其他组织或器官,发生与多种因素有关,如经血倒流、遗传、手术等,EMs临床表现为痛经、月经不调,甚至不孕,虽然EMs属于良性疾病,但具有恶性肿瘤特性,可发生恶变。程序性细胞死亡因子4(PDCD4)基因是一种新型的抑癌基因,其功能丧失与子宫内膜病变的发生、发展密切相关。自噬可能参与了EMs的病理过程,其能促进内膜细胞死亡,而PDCD4参与了自噬的调控,因而PDCD4可通过调控自噬影响EMs。深入研究PDCD4与EMs的关系,可为EMs的治疗提供新的途径。

Endometriosis(EMs)is an endometriotic disease,which refers to endometrial appearing in other tissue or organ outside the uterus,related to various factors such as retrograde menstruation,heredity,surgery,and so on.The clinical manifestations of EMs are dysmenorrhea,irregular menstruation,and even infertility.Although EMs is a benign disease,it has malignant tumor characteristics and can cause malignant transformation.The programmed cell death 4(PDCD4)gene is a novel tumor suppressor gene,the function loss of which is closely related to the occurrence and development of endometrial lesions.Autophagy may be involved in the pathological process of EMs,which can promote intimal cell death,and PDCD4 is involved in the regulation of autophagy,so PDCD4 can affect EMs by regulating autophagy.An in-depth study of the relationship between PDCD4 and EMs may provide a new approach to the treatment of EMs.