非酒精性脂肪性肝病相关肝细胞癌发病机制研究进展

Research Progress in Pathogenesis of Non-Alcoholic Fatty Liver Disease-Related Hepatocellular Carcinoma

非酒精性脂肪性肝病(NAFLD)是以肝脏脂肪堆积异常、炎症和肝细胞功能障碍为特征的肝脏疾病的总称,是全世界最常见的慢性肝脏疾病之一。近年来,NAFLD相关肝细胞癌(NAFLD-HCC)数量日益增多,对NAFLD-HCC发病机制的研究也日益深入。NAFLD-HCC发病机制的复杂性成为其有效治疗的主要障碍,主要与代谢综合征、肠道微生物、基因、促炎细胞因子、脂肪细胞因子、自噬等相关,深入研究其发病机制可为NAFLD-HCC的诊断和治疗提供更大的帮助。

Non-alcoholic fatty liver disease(NAFLD)includes a series of liver diseases characterized by abnormal liver fat accumulation,inflammation and hepatocyte dysfuntion.It is one of the most common chronic liver diseases in the world.In recent years,the number of NAFLD-related hepatocellular carcinoma(NAFLD-HCC)has been increasing,and the study of NAFLD-HCC pathogenesis has been continuously deepening.The complex factors of the pathogenesis of NAFLD-HCC have been the main obstacle to the effective treatment,including metabolic syndrome,intestinal microbes,genes,proinflammatory cytokines,adipocytokines,autophagy,etc.Further study of the pathogenesis of NAFLD-HCC may provide greater help to the diagnosis and treatment.