高尿酸血症与早发冠心病的相关性研究进展

Research Progress in Relationship between Hyperuricemia and Early-Onset Coronary Artery Disease

近年来,早发冠心病的发病率和病死率呈逐年增多的趋势,严重威胁着人类的健康。血尿酸水平升高在促进动脉粥样硬化发生、发展的过程中扮演着重要角色。高尿酸血症可能是早发冠心病的独立危险因素之一,但高尿酸血症也与其他因素协同起作用。对于早发冠心病患者早期采取有效措施,积极控制血尿酸水平,可延缓冠状动脉病变的发生和发展,在一定程度上减少心血管事件的发生,改善患者预后,提高患者的生存质量。

In recent years,the incidence and mortality of premature coronary heart disease have increased year by year,which is a serious threat to human health.Elevated levels of serum uric acid play an important role in promoting the onset and progression of atherosclerosis.Hyperuricemia may be one of the independent risk factors for premature coronary heart disease,but hyperuricemia also works synergistically with other factors.Effective measures for early-onset coronary heart disease patients,active control of blood uric acid levels,can delay the occurrence and development of coronary artery disease,reduce the occurrence of cardiovascular events,and improve prognosis and quality of life for the patients to some extent.