来氟米特在肾脏疾病中的应用进展

Application Progress of Leflunomide in Renal Diseases

来氟米特是一种人工合成的异口恶唑类药物,通过尿液及胆汁经粪便排泄。其新颖的作用机制使其具有免疫抑制、抗增殖及抗病毒等作用,具有明确的疗效和较好的安全性。过去已广泛运用于各类自身免疫疾病,如类风湿关节炎、系统性红斑狼疮等。随着对该药物的进一步研究,来氟米特对于一些免疫介导性疾病,如肾小球疾病、移植、皮肤病等亦有较好的疗效。但因其具有免疫抑制、抗增殖等作用,故未来需进一步探究在保证疗效的前提下降低该药物不良反应发生率,寻求最佳治疗方案。

Leflunomide is a synthetic isoxazole,which is in the urine and bile excretion through the feces.Its novel mechanism makes it immunosuppressive,anti-proliferative and anti-viral,with clear curative effect and good safety.In the past,it has been widely used in various autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus.With the deepening research of this drug,leflunomide is used for some immune-mediated diseases such as glomerular diseases,transplantation,skin diseases,etc.with good effect.However,due to its immunosuppressive and anti-proliferative effects,it is necessary to explore the adverse reactions under the premise of ensuring the efficacy,and seek the optimal treatment in the future.