脑外伤后情绪障碍者面孔表情ERP晚期正成分分析

Analysis of Late Positive Component of Event-related Potentials by Face Expression Images in Traumatic Brain Injury Patients with Mood Disorders

目的探讨正性、负性及中性面孔刺激范式事件相关电位(event-related potential,ERP)在脑外伤者情绪障碍评定中的应用价值。方法对24例以焦虑忧郁症状为主的情绪障碍者(忧郁组)和19例以敌对猜疑症状为主的情绪障碍者(敌对组)分别进行面孔刺激范式ERP检测,比较其与正常对照组的差异。结果正性、负性和中性3类图片刺激诱发的ERP晚期正成分(late positive potential,LPP)潜伏期及波幅(负性图片刺激诱发的波幅除外)在忧郁组及敌对组间差异均无统计学意义,两组LPP潜伏期较正常对照组均延长,LPP波幅较正常对照组均降低。在相同组内,3类图片刺激诱发的LPP潜伏期差异无统计学意义,负性图片刺激诱发的LPP波幅均高于中性、正性图片刺激诱发的LPP波幅,敌对组与正常对照组波幅差异具有统计学意义(P<0.05),而忧郁组内波幅差异无统计学意义。结论 LPP潜伏期、波幅的变化可作为脑外伤者情绪障碍评定的客观指标,负性情绪诱发的LPP对忧郁为主的情绪障碍的评估更有意义。

Objective To explore the application of event-related potentials(ERP)by positive,negative,and neutral face expression images in the evaluation of mood disorders in brain traumatic patients.Methods ERP was tested by face expression images in 24 patients mainly with anxiety and depression symptoms(depression group)and 19 patients mainly with hostile and suspicion symptoms(hostile group),respectively.The findings were compared with those of the control group.Results There were no significant differences,between the depression group and the hostile group,on latencies and amplitudes of late positive potential(LPP)induced by the three types of face expression images,except the amplitude induced by negative face expression image.Compared with the control group,the latencies were extended and the amplitudes were lower in both depression and hostile groups.Within each group,the difference of latencies induced by the three images was not significant.The amplitudes induced by negative face expression image was higher than those induced by positive and neutral face expression images,with significant differences in the hostile group and the control group(P<0.05)but not in the depression group.Conclusion Changes in latencies and amplitudes of LPP could be an objective indicator in the evaluation of mood disorders of brain traumatic patients.The LPP induced by negative face expression images could be more meaningful for patients mainly with anxiety and depression symptoms.