杨桃根水提取物化学成分及生物活性的研究

Chemical constituents of the water extracts of Averrhoa carambola L. root and their biological activities

为探究杨桃根中具备降血糖功能的活性成分,采用色谱分离方法从其水提取物中分离得到9个化合物,应用波谱技术对它们的化学结构进行了鉴定,分别命名为prismaconnatoside(1),tarennanosides A(2),(+)-catechin(3),fernandoside(4),7a-[(β-glucopyranosyl) oxy]-lyoniresinol(5),(+)-lyoniresinol 3α-O-β-D-glucopyranoside(6),(-)-lyon-iresinol 3α-O-β-D-glucopyranoside(7),(-)-5’-methoxy-isolariciresinol 3α-O-β-D-glucopyranoside(8)和正辛烷(9)。其中化合物1,2,4,5均为首次从杨桃中分离得到,化合物3为首次从杨桃根中分离得到。对部分单体化合物进行了体外α-葡萄糖苷酶和DPP-IV酶抑制活性测试,化合物1具有较强的α-葡萄糖苷酶抑制活性。

To further investigate the antidiabetic constituents from the root of Averrhoa carambola L.,nine compounds were isolated from the water extracts by series column chromatographies and their structures were identified as prismaconnatoside(1),tarennanosides A(2),(+)-catechin(3),fernandoside(4),7a-[(β-glucopyranosyl)oxy]-lyoniresinol(5),(+)-lyoniresinol 3 α-O-β-D-glucopyranoside(6),(-)-lyoniresinol 3α-O-β-D-glucopyranoside(7),(-)-5’-methoxy-isolariciresinol 3α-O-β-D-glucopyranoside(8),and n-octane(9).Compounds 1,2,4,and 5 were isolated from Averrhoa carambola for the first time.Compound 3 was isolated from the root part of Averrhoa carambola for the first time.Some compounds were assayed for the α-glucosidase and DPP-IV inhibitory activities in vitro.Compound 1 showed α-glucosidase inhibitory activity.