高危型人乳头瘤病毒感染与阴道微生态的关系

The relationship between high-risk human papillomavirus infection and vaginal microecology

目的:探讨高危型人乳头瘤病毒(HR-HPV)感染与阴道微生态变化的关系。方法:收集2016年11月至2017年10月宁波市中医院妇科就诊的HR-HPV感染阳性者60例为感染组,HR-HPV感染阴性者60例为对照组,对2组患者进行阴道微生态检查,分析阴道微生态检查结果与HR-HPV感染的关系。对清洁度、pH值、过氧化氢浓度、白细胞酯酶、细菌性阴道病(BV)、需氧性阴道炎(AV)、滴虫性阴道炎(TV)、外阴阴道假丝酵母菌病(VVC)和混合性感染这9个指标进行单因素分析。将HR-HPV感染作为因变量进行logistic回归分析。结果:2组患者清洁度、pH值、过氧化氢浓度、白细胞酯酶、BV差异有统计学意义(P<0.05)。清洁度、p H值、BV是HR-HPV感染的危险因素(OR=8.389、3.736、4.222)。结论:阴道微生态的失衡与HR-HPV感染密切相关,清洁度III°~IV°、p H值>4.5、BV是HR-HPV感染的危险因素。

Objective: To explore the relationship between HR-HPV infection and the microecological changes of vagina.Methods: From November 2016 to October 2017,sixty cases of HR-HPV infection positive in the Gynecology Department of Ningbo Hospital of TCM were selected as infection group,and sixty cases with HR-HPV infection negative were collected as control group.Two groups were examined for vaginal microecology,and the relationship between the results of vaginal microecological examination and HR-HPV infection was analyzed.The nine indicators including vaginal cleanliness,vaginal pH,hydrogen peroxide concentration,leukocyte esterase,bacterial vaginosis,aerobic vaginitis,trichomonal vaginitis,vulvovaginal candidiasis and mixed infection were analyzed by single factor.Taking the HR-HPV infection as the dependent variable to conduct logistic regression analysis.Results: There were significant differences in vaginal cleanliness,vaginal pH,hydrogen peroxide concentration,leukocyte esterase and BV between the two groups (P<0.05).It was showed that vaginal cleanliness,vaginal pH and BV were the risk factors of the HR-HPV infection (OR=8.389,3.736,4.222).Conclusion: The imbalance of vagina microecology is closely related to HR-HPV infection.Vaginal cleanliness degree III-IV,vaginal pH greater than 4.5 and BV are the risk factors of HR-HPV infection.